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[5]\n\n CBD\u304a\u3088\u3073\u767a\u4f5c\u969c\u5bb3\u85ac\n\n \u85ac\u7269\u3068CBD\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u767a\u4f5c\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u4eba\u3001\u7279\u306b\u9ad8\u7528\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306e\u9593\u3067\u4e00\u822c\u7684\u3067\u3059\u3002 CBD\u304c\u6b21\u306e\u85ac\u306eCBD\u8840\u6db2\u6fc3\u5ea6\u3068\u4f75\u305b\u3066\u6295\u4e0e\u3055\u308c\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306b\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n\n\n\n  \u30c8\u30d4\u30e9\u30e1\u30fc\u30c8\n \n\n  \u30eb\u30d5\u30a3\u30ca\u30df\u30c9\n \n\n  n-des-methylclobazam\uff08\u85ac\u7269\u30af\u30ed\u30d0\u30b6\u30e0\u306e\u6d3b\u6027\u4ee3\u8b1d\u7269\uff09\n \n\n  \u30be\u30cb\u30b5\u30df\u30c9\n \n\n  Eslicarbazepine\n \n\n  CBD\u3068\u767a\u4f5c\u85ac\u306e\u30d0\u30eb\u30d7\u30ed\u9178\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u60a3\u8005\u306f\u3001\u6f5c\u5728\u7684\u306a\u554f\u984c\u306b\u3064\u3044\u3066\u809d\u6a5f\u80fd\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n \n    CBD\u304a\u3088\u3073\u30b9\u30bf\u30c1\u30f3\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u85ac\n\n  \u30b9\u30bf\u30c1\u30f3\u306f\u3001\u9175\u7d20CYP3A4\u3092\u4ecb\u3057\u3066\u51e6\u7406\u3055\u308c\u308b\u305f\u3081\u3001CBD\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u85ac\u7269\u30d5\u30a1\u30df\u30ea\u30fc\u306e1\u3064\u3067\u3059\u3002 CBD\u3068\u30b9\u30bf\u30c1\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u3001\u7406\u8ad6\u7684\u306b\u306f\u4f53\u5185\u306e\u30b9\u30bf\u30c1\u30f3\u306e\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306f\u3001CBD\u3092\u4f7f\u7528\u3057\u3066\u6cbb\u7642\u3059\u308b\u75c7\u72b6\u306b\u5178\u578b\u7684\u3067\u985e\u4f3c\u3057\u305f\u526f\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30b9\u30bf\u30c1\u30f3\u306fCBD\u3068\u306e\u4e92\u63db\u6027\u3082\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u591a\u304f\u306e\u30b9\u30bf\u30c1\u30f3\u85ac\u306f\u3001\u8a18\u61b6\u3001\u7b4b\u8089\u306e\u75db\u307f\u3001\u75b2\u52b4\u3001\u7b4b\u8089\u306e\u8870\u5f31\u306b\u95a2\u3059\u308b\u554f\u984c\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n \n\n  \u3059\u3067\u306b\u30b9\u30bf\u30c1\u30f3\u85ac\u306e\u6bce\u65e5\u306e\u6700\u5927\u6295\u4e0e\u91cf\u3092\u6442\u53d6\u3057\u3066\u3044\u308b\u6162\u6027\u75bc\u75db\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u304b\u306a\u308a\u306e\u6570\u306e\u60a3\u8005\u304c\u898b\u3089\u308c\u308b\u306e\u3067\u3001\u79c1\u306f\u3057\u3070\u3057\u3070\u533b\u5e2b\u3068\u4ee3\u66ff\u6cbb\u7642\u306b\u3064\u3044\u3066\u8a71\u3057\u5408\u3044\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306e\u6f5c\u5728\u7684\u306a\u60aa\u5f71\u97ff\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u3001\u73fe\u5728\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u30b9\u30bf\u30c1\u30f3\u306e\u6295\u4e0e\u91cf\u3092\u6e1b\u3089\u3059\u304b\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u3092\u542b\u3080\u3002\n \n    CBD\u304a\u3088\u3073\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3068\u30a2\u30be\u30fc\u30eb\u6297\u771f\u83cc\n\n  \u6297\u751f\u7269\u8cea\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3068\u6297\u771f\u83cc\u6027\u30a2\u30be\u30fc\u30eb\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001CBD\u3092\u4ee3\u8b1d\u3059\u308b\u539f\u56e0\u3068\u306a\u308bCYP\u9175\u7d20\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac\u7269\u3067\u3059\u3002\u305d\u308c\u3089\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u7406\u8ad6\u7684\u306b\u306f\u5426\u5b9a\u7684\u306a\u7d50\u679c\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n \n    CBD\u304a\u3088\u3073\u6297\u3046\u3064\u85ac\"> cbd\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3001\u3055\u307e\u3056\u307e\u306a\u8840\u6db2\u8584\u3044\n\n \u79c1\u306f\u3057\u3070\u3057\u3070\u3001\u8840\u6db2\u30b7\u30f3\u30ca\u30fc\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\uff08\u30d6\u30e9\u30f3\u30c9\u30af\u30de\u30c7\u30a3\u30f3\uff08R\uff09\u3068Jantoven\uff08R\uff09\u306b\u3088\u3063\u3066\u3082\u547c\u3070\u308c\u308b\uff09\u3067\u7d4c\u9a13\u3067\u304d\u308b\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u5c0b\u306d\u3089\u308c\u307e\u3059\u3002\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068THC\u306e\u4e21\u65b9\u304cCYP2C9\u3068\u547c\u3070\u308c\u308b\u809d\u81d3\u306e\u9175\u7d20\u3092\u4ecb\u3057\u3066\u51e6\u7406\u3055\u308c\u308b\u305f\u3081\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068THC\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3059\u308b\u6700\u3082\u91cd\u8981\u306a\u554f\u984c\u3002\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068THC\u304c\u3053\u306e\u9175\u7d20\u3068\u7af6\u5408\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306e\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3057\u3001\u51fa\u8840\u306e\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u306f\u3001\u6cbb\u7642\u306bTHC\u3092\u542b\u3080\u5927\u9ebb\u3092\u8ffd\u52a0\u3057\u305f\u5f8c\u3001\u30c1\u30a7\u30c3\u30af\u3055\u308c\u305f\u8840\u6db2INR\u30ec\u30d9\u30eb\u3092\u691c\u67fb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n\n\n \u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u307e\u305f\u306f\u4ed6\u306e\u8840\u6db2\u30b7\u30f3\u30ca\u30fc\u3068\u4e00\u7dd2\u306b\u5927\u91cf\u306eCBD\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u30cd\u30ac\u30c6\u30a3\u30d6\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001CBD\uff08CYP2C19\uff09\u3092\u4ee3\u8b1d\u3059\u308b\u9175\u7d20\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u5371\u967a\u306f\u305d\u308c\u307b\u3069\u91cd\u8981\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u30b1\u30fc\u30b9\u30ec\u30dd\u30fc\u30c8\u304c\u767a\u8868\u3055\u308c\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306e\u7528\u91cf\u3092\u958b\u59cb\u3057\u3001CBD\u3092\u975e\u5e38\u306b\u9ad8\u3044\u7528\u91cf\u306b\u5f90\u3005\u306b\u5897\u52a0\u3055\u305b\u308b\u5fc5\u8981\u6027\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002 [3]\n\n\n \u3053\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u3066\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068\u4f75\u305b\u3066\u5927\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u533b\u5e2b\u306b\u901a\u77e5\u3057\u3001\u8840\u6db2\u3092\u691c\u67fb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u306e\u7df4\u7fd2\u3067\u306f\u3001\u60a3\u8005\u304cCBD\u3092\u670d\u7528\u3057\u305f\u5f8c\u3001INR\u306e\u5897\u52a0\u3092\u898b\u3066\u3044\u307e\u305b\u3093\u3002\n\n\n \u3055\u3089\u306b\u3001CBD\u3068Apixaban\u3084Rivaroxaban\u306a\u3069\u306e\u7d4c\u53e3\u6297\u51dd\u56fa\u5264\u3068\u306e\u9593\u306b\u306f\u3001\u51fa\u8840\u306e\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308bCYP3A\u9175\u7d20\uff08\u304a\u3088\u3073P-GP\u6d41\u51fa\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff09\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 CBD\u304a\u3088\u3073\u3053\u308c\u3089\u306e\u85ac\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u79d1\u5b66\u6587\u732e\u306b\u8a18\u9332\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3053\u308c\u3089\u306e\u85ac\u7269\u7642\u6cd5\u3068\u5927\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u6cbb\u7642\u304c\u7c21\u5358\u306a\u51fa\u8840\u3068\u6253\u64b2\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 [4]\n\n\n \u6297\u8840\u5c0f\u677f\u85ac\u7269\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u306f\u3001CYP2C19\u3092\u4ecb\u3057\u3066\u3001\u3088\u308a\u5c11\u306a\u3044\u91cf\u3067CYP3A4\u3092\u4ecb\u3057\u3066\u305d\u306e\u6d3b\u6027\u578b\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u3068\u4e00\u7dd2\u306bCBD\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u306e\u6cbb\u7642\u52b9\u679c\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u533b\u5e2b\u306f\u8840\u5c0f\u677f\u306e\u9069\u5207\u306a\u53cd\u5fdc\u3068\u51dd\u96c6\u3092\u30c1\u30a7\u30c3\u30af\u3059\u308b\u3053\u3068\u3092\u6c7a\u5b9a\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u7d14\u7c8b\u306b\u7406\u8ad6\u7684\u3067\u3042\u308a\u3001\u7814\u7a76\u6587\u732e\u306b\u306f\u30b1\u30fc\u30b9\u30b9\u30bf\u30c7\u30a3\u306f\u3042\u308a\u307e\u305b\u3093\u3002 [5]\n\n CBD\u304a\u3088\u3073\u767a\u4f5c\u969c\u5bb3\u85ac\n\n \u85ac\u7269\u3068CBD\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u767a\u4f5c\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u4eba\u3001\u7279\u306b\u9ad8\u7528\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306e\u9593\u3067\u4e00\u822c\u7684\u3067\u3059\u3002 CBD\u304c\u6b21\u306e\u85ac\u306eCBD\u8840\u6db2\u6fc3\u5ea6\u3068\u4f75\u305b\u3066\u6295\u4e0e\u3055\u308c\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306b\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n\n\n\n  \u30c8\u30d4\u30e9\u30e1\u30fc\u30c8\n \n\n  \u30eb\u30d5\u30a3\u30ca\u30df\u30c9\n \n\n  n-des-methylclobazam\uff08\u85ac\u7269\u30af\u30ed\u30d0\u30b6\u30e0\u306e\u6d3b\u6027\u4ee3\u8b1d\u7269\uff09\n \n\n  \u30be\u30cb\u30b5\u30df\u30c9\n \n\n  Eslicarbazepine\n \n\n  CBD\u3068\u767a\u4f5c\u85ac\u306e\u30d0\u30eb\u30d7\u30ed\u9178\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u60a3\u8005\u306f\u3001\u6f5c\u5728\u7684\u306a\u554f\u984c\u306b\u3064\u3044\u3066\u809d\u6a5f\u80fd\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n \n    CBD\u304a\u3088\u3073\u30b9\u30bf\u30c1\u30f3\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u85ac\n\n  \u30b9\u30bf\u30c1\u30f3\u306f\u3001\u9175\u7d20CYP3A4\u3092\u4ecb\u3057\u3066\u51e6\u7406\u3055\u308c\u308b\u305f\u3081\u3001CBD\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u85ac\u7269\u30d5\u30a1\u30df\u30ea\u30fc\u306e1\u3064\u3067\u3059\u3002 CBD\u3068\u30b9\u30bf\u30c1\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u3001\u7406\u8ad6\u7684\u306b\u306f\u4f53\u5185\u306e\u30b9\u30bf\u30c1\u30f3\u306e\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306f\u3001CBD\u3092\u4f7f\u7528\u3057\u3066\u6cbb\u7642\u3059\u308b\u75c7\u72b6\u306b\u5178\u578b\u7684\u3067\u985e\u4f3c\u3057\u305f\u526f\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30b9\u30bf\u30c1\u30f3\u306fCBD\u3068\u306e\u4e92\u63db\u6027\u3082\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u591a\u304f\u306e\u30b9\u30bf\u30c1\u30f3\u85ac\u306f\u3001\u8a18\u61b6\u3001\u7b4b\u8089\u306e\u75db\u307f\u3001\u75b2\u52b4\u3001\u7b4b\u8089\u306e\u8870\u5f31\u306b\u95a2\u3059\u308b\u554f\u984c\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n \n\n  \u3059\u3067\u306b\u30b9\u30bf\u30c1\u30f3\u85ac\u306e\u6bce\u65e5\u306e\u6700\u5927\u6295\u4e0e\u91cf\u3092\u6442\u53d6\u3057\u3066\u3044\u308b\u6162\u6027\u75bc\u75db\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u304b\u306a\u308a\u306e\u6570\u306e\u60a3\u8005\u304c\u898b\u3089\u308c\u308b\u306e\u3067\u3001\u79c1\u306f\u3057\u3070\u3057\u3070\u533b\u5e2b\u3068\u4ee3\u66ff\u6cbb\u7642\u306b\u3064\u3044\u3066\u8a71\u3057\u5408\u3044\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306e\u6f5c\u5728\u7684\u306a\u60aa\u5f71\u97ff\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u3001\u73fe\u5728\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u30b9\u30bf\u30c1\u30f3\u306e\u6295\u4e0e\u91cf\u3092\u6e1b\u3089\u3059\u304b\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u3092\u542b\u3080\u3002\n \n    CBD\u304a\u3088\u3073\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3068\u30a2\u30be\u30fc\u30eb\u6297\u771f\u83cc\n\n  \u6297\u751f\u7269\u8cea\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3068\u6297\u771f\u83cc\u6027\u30a2\u30be\u30fc\u30eb\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001CBD\u3092\u4ee3\u8b1d\u3059\u308b\u539f\u56e0\u3068\u306a\u308bCYP\u9175\u7d20\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac\u7269\u3067\u3059\u3002\u305d\u308c\u3089\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u7406\u8ad6\u7684\u306b\u306f\u5426\u5b9a\u7684\u306a\u7d50\u679c\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n \n    CBD\u304a\u3088\u3073\u6297\u3046\u3064\u85ac<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/old.hemppedia.org\/ja\/cbd%e3%81%a8%e8%96%ac%e7%89%a9%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e6%82%a3%e8%80%85%e3%81%ae%e3%82%ac%e3%82%a4%e3%83%89\/#CBD%E3%81%8A%E3%82%88%E3%81%B3%E7%B7%91%E5%86%85%E9%9A%9C\" title=\"\n  CBD\u304a\u3088\u3073\u7dd1\u5185\u969c \n \">\n  CBD\u304a\u3088\u3073\u7dd1\u5185\u969c \n <\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/old.hemppedia.org\/ja\/cbd%e3%81%a8%e8%96%ac%e7%89%a9%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e6%82%a3%e8%80%85%e3%81%ae%e3%82%ac%e3%82%a4%e3%83%89\/#%E5%8F%82%E7%85%A7\" title=\"\u53c2\u7167\">\u53c2\u7167<\/a><\/li><\/ul><\/nav><\/div>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-top\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;118301&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;top&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;0&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;0&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;4&quot;,&quot;greet&quot;:&quot;Rate post&quot;,&quot;legend&quot;:&quot;0\\\/5 - (0)&quot;,&quot;size&quot;:&quot;20&quot;,&quot;title&quot;:&quot;CBD\\u3068\\u85ac\\u7269\\u76f8\\u4e92\\u4f5c\\u7528\\u306b\\u95a2\\u3059\\u308b\\u60a3\\u8005\\u306e\\u30ac\\u30a4\\u30c9&quot;,&quot;width&quot;:&quot;0&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 0px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 16px;\">\n            <span class=\"kksr-muted\">Rate post<\/span>\n    <\/div>\n    <\/div>\n<p>\u7814\u7a76\u3067\u306f\u3001CBD\u304c\u5b89\u5168\u306a\u7269\u8cea\u3068\u3057\u3066\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u65b0\u3057\u3044\u85ac\u3068\u540c\u69d8\u306b\u3001\u4ed6\u306e\u85ac\u7269\u3068\u5e72\u6e09\u3057\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<p>\n \u30ab\u30f3\u30ca\u30d3\u30b8\u30aa\u30fc\u30eb\uff08CBD\uff09\u306f\u3001\u904b\u52d5\u5f8c\u306e\u708e\u75c7\u3084\u75db\u307f\u306e\u6e1b\u5c11\u3084\u4e0d\u7720\u75c7\u306e\u7de9\u548c\u3001\u6c17\u5206\u3001\u7126\u70b9\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u51e6\u3059\u308b\u80fd\u529b\u306e\u6539\u5584\u306a\u3069\u3001\u591a\u6570\u306e\u5065\u5eb7\u4e0a\u306e\u5229\u70b9\u3092\u6301\u3064\u975e\u5e38\u306b\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u6210\u5206\u306b\u306a\u308a\u307e\u3059\u3002\n<\/p>\n<p>\n CBD\u306f\u7121\u6bd2\u3067\u3042\u308a\u3001\u5bb3\u3092\u53ca\u307c\u3055\u306a\u3044\u5b89\u5168\u306a\u85ac\u7269\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u6570\u306e\u7814\u7a76\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u7269\u8cea\u3067\u3082\u3042\u308a\u307e\u3059\u3002 CBD\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30ebCBD\u306f\u3001\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306e\u3088\u3046\u306a\u4e3b\u8981\u306a\u4fdd\u5065\u6a5f\u95a2\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u3066\u304a\u308a\u3001\u52d5\u7269\u3068\u4eba\u9593\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066\u5fcd\u5bb9\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\n<\/p>\n<p>\n CBD\u306f\u4ed6\u306e\u591a\u304f\u306e\u85ac\u7269\u3068\u4e00\u7dd2\u306b\u5b89\u5168\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059\u304c\u3001\u4ed6\u306e\u85ac\u3068\u554f\u984c\u306e\u3042\u308b\u76f8\u4e92\u4f5c\u7528\u3092\u4f5c\u6210\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001CBD\u306f\u809d\u81d3\u306e\u4ee3\u8b1d\u3092\u4ecb\u3057\u3066\u4ed6\u306e\u85ac\u7269\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u307e\u3059\u3002\n<\/p>\n<p>\n \u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u8d77\u3053\u308b\u7406\u7531\u3068\u65b9\u6cd5\u306e\u7406\u7531\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u3001CBD\u306e\u51e6\u7406\u306b\u8eab\u4f53\u304c\u5229\u7528\u3059\u308b\u809d\u81d3\u9175\u7d20\u306b\u3088\u3063\u3066\u540c\u3058\u65b9\u6cd5\u3067\u51e6\u7406\u3055\u308c\u308b\u3055\u307e\u3056\u307e\u306a\u30af\u30e9\u30b9\u306e\u85ac\u7269\u306b\u3064\u3044\u3066\u3082\u8aac\u660e\u3057\u307e\u3059\u3002\n<\/p>\n<p>\n \u7559\u610f\u3059\u3079\u304d\u6700\u3082\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002\n<\/p>\n<ul>\n<li>\n  CBD\u306f\u3001\u8077\u4eba\u88fd\u54c1\u306e\u5927\u591a\u6570\u306e\u30e6\u30fc\u30b6\u30fc\u304c\u4f7f\u7528\u3059\u308b\u4f4e\u7528\u91cf\u307e\u305f\u306f\u4e2d\u7a0b\u5ea6\u306e\u7528\u91cf\u3067\u85ac\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3067\u3059\u3002\u79d1\u5b66\u6587\u732e\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u901a\u5e38\u3001\u3066\u3093\u304b\u3093\u3084\u4ed6\u306e\u969c\u5bb3\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u4f7f\u7528\u3055\u308c\u308b\u975e\u5e38\u306b\u5927\u304d\u306a\u7528\u91cf\u3067\u767a\u751f\u3057\u307e\u3059\u3002 [1]\n <\/li>\n<li>\n  \u6700\u3082\u91cd\u8981\u306a\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u306f\u3001CBD\u304a\u3088\u3073\u4ed6\u306e\u7269\u8cea\u306e\u4ee3\u8b1d\u306b\u5229\u7528\u3055\u308c\u308bCYP450\u4ee3\u8b1d\u7d4c\u8def\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u3067\u7279\u5b9a\u3067\u304d\u307e\u3059\u3002\n <\/li>\n<\/ul>\n<p>\n <b><\/p>\n<h2><span class=\"ez-toc-section\" id=\"CBD%E8%96%AC%E7%89%A9%E7%9B%B8%E4%BA%92%E4%BD%9C%E7%94%A8%E3%81%AF%E3%81%A9%E3%81%AE%E3%82%88%E3%81%86%E3%81%AB%E7%99%BA%E7%94%9F%E3%81%97%E3%81%BE%E3%81%99%E3%81%8B%EF%BC%9F\"><\/span> CBD\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u306f\u3069\u306e\u3088\u3046\u306b\u767a\u751f\u3057\u307e\u3059\u304b\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p> <\/b>\n<\/p>\n<p>\n \u4ee3\u8b1d\u3001\u5438\u53ce\u3001\u304a\u3088\u3073\u7269\u8cea\u306e\u3044\u305a\u308c\u304b\u307e\u305f\u306f\u4e21\u65b9\u306e\u6392\u6cc4\uff08\u85ac\u7269\u52d5\u614b\u76f8\u4e92\u4f5c\u7528\uff09\u306e\u6392\u6cc4\u3092\u5909\u3048\u308b\u85ac\u7269\u3068\u3001\u85ac\u7269\u306e\u4f5c\u7528\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\uff08\u85ac\u7269\u529b\u5b66\u7684\u76f8\u4e92\u4f5c\u7528\uff09\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u85ac\u7269\u3068\u306e\u9593\u306b\u306f\u30012\u7a2e\u985e\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002 CBD\u306e\u3088\u3046\u306a\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306b\u306f\u3001\u4ed6\u306e\u85ac\u7269\u3068\u5171\u6709\u3055\u308c\u3001\u4ed6\u306e\u85ac\u7269\u3068\u540c\u69d8\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5171\u6709\u3059\u308b\u4ee3\u8b1d\u7d4c\u8def\u304c\u3042\u308b\u305f\u3081\u3001\u76f8\u4e92\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4ed6\u306e\u85ac\u3068CBD\u306b\u81e8\u5e8a\u7684\u306b\u95a2\u9023\u3059\u308b\u76f8\u4e92\u4f5c\u7528\u306e\u5927\u90e8\u5206\u306f\u3001\u809d\u81d3\u306e\u89e3\u6bd2\u7d4c\u8def\u5185\u306e\u7af6\u4e89\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u6642\u306b\u306f\u3001\u3053\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u3001\u4ee3\u8b1d\u3092\u9045\u304f\u3057\u3001\u4f53\u5185\u306e\u85ac\u7269\u306e\u30ec\u30d9\u30eb\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5404\u85ac\u7269\u304c\u5f37\u304f\u306a\u308a\u307e\u3059\u3002\u3042\u308b\u3044\u306f\u3001\u305d\u308c\u305e\u308c\u304c\u4ed6\u306e\u4ee3\u8b1d\u3092\u5897\u3084\u3059\u3053\u3068\u306b\u3088\u308a\u3001\u4ed6\u306e\u4eba\u3078\u306e\u5f71\u97ff\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3069\u3061\u3089\u3082\u671b\u307e\u3057\u304f\u306a\u3044\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<p>\n \u85ac\u7269\u306e\u4ee3\u8b1d\u306b\u5f79\u7acb\u3064\u9175\u7d20\u306eCYP450\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u542b\u308050\u3092\u8d85\u3048\u308b\u809d\u81d3\u9175\u7d20\u306e\u3046\u3061\u30012\u3064\u306e\u9175\u7d20\u304cCBD\u306e\u4ee3\u8b1d\u306e\u539f\u56e0\u3068\u306a\u308b\u4e3b\u8981\u306a\u9175\u7d20\u3067\u3042\u308bCYP3A4\u304a\u3088\u3073CYP2C19\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u9175\u7d20\u3092\u77e5\u308b\u3053\u3068\u306f\u3001\u3042\u306a\u305f\u306e\u533b\u7642\u5c02\u9580\u5bb6\u307e\u305f\u306f\u3042\u306a\u305f\u304c\u85ac\u7269\u306e\u4ee3\u8b1d\u30d7\u30ed\u30bb\u30b9\u3092\u6c7a\u5b9a\u3057\u3001CBD-DRUG\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u53ef\u80fd\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\n<\/p>\n<p>\n 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\u79c1\u306f\u3057\u3070\u3057\u3070\u3001\u8840\u6db2\u30b7\u30f3\u30ca\u30fc\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\uff08\u30d6\u30e9\u30f3\u30c9\u30af\u30de\u30c7\u30a3\u30f3\uff08R\uff09\u3068Jantoven\uff08R\uff09\u306b\u3088\u3063\u3066\u3082\u547c\u3070\u308c\u308b\uff09\u3067\u7d4c\u9a13\u3067\u304d\u308b\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u5c0b\u306d\u3089\u308c\u307e\u3059\u3002\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068THC\u306e\u4e21\u65b9\u304cCYP2C9\u3068\u547c\u3070\u308c\u308b\u809d\u81d3\u306e\u9175\u7d20\u3092\u4ecb\u3057\u3066\u51e6\u7406\u3055\u308c\u308b\u305f\u3081\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068THC\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3059\u308b\u6700\u3082\u91cd\u8981\u306a\u554f\u984c\u3002\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068THC\u304c\u3053\u306e\u9175\u7d20\u3068\u7af6\u5408\u3057\u3066\u3044\u308b\u5834\u5408\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306e\u30ec\u30d9\u30eb\u304c\u4e0a\u6607\u3057\u3001\u51fa\u8840\u306e\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u306f\u3001\u6cbb\u7642\u306bTHC\u3092\u542b\u3080\u5927\u9ebb\u3092\u8ffd\u52a0\u3057\u305f\u5f8c\u3001\u30c1\u30a7\u30c3\u30af\u3055\u308c\u305f\u8840\u6db2INR\u30ec\u30d9\u30eb\u3092\u691c\u67fb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<p>\n \u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u307e\u305f\u306f\u4ed6\u306e\u8840\u6db2\u30b7\u30f3\u30ca\u30fc\u3068\u4e00\u7dd2\u306b\u5927\u91cf\u306eCBD\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u30cd\u30ac\u30c6\u30a3\u30d6\u306a\u76f8\u4e92\u4f5c\u7528\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001CBD\uff08CYP2C19\uff09\u3092\u4ee3\u8b1d\u3059\u308b\u9175\u7d20\u304c\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u5371\u967a\u306f\u305d\u308c\u307b\u3069\u91cd\u8981\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u30b1\u30fc\u30b9\u30ec\u30dd\u30fc\u30c8\u304c\u767a\u8868\u3055\u308c\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306e\u7528\u91cf\u3092\u958b\u59cb\u3057\u3001CBD\u3092\u975e\u5e38\u306b\u9ad8\u3044\u7528\u91cf\u306b\u5f90\u3005\u306b\u5897\u52a0\u3055\u305b\u308b\u5fc5\u8981\u6027\u3092\u5b9f\u8a3c\u3057\u307e\u3057\u305f\u3002 [3]\n<\/p>\n<p>\n \u3053\u306e\u7814\u7a76\u306b\u57fa\u3065\u3044\u3066\u3001\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068\u4f75\u305b\u3066\u5927\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u533b\u5e2b\u306b\u901a\u77e5\u3057\u3001\u8840\u6db2\u3092\u691c\u67fb\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u79c1\u306e\u7df4\u7fd2\u3067\u306f\u3001\u60a3\u8005\u304cCBD\u3092\u670d\u7528\u3057\u305f\u5f8c\u3001INR\u306e\u5897\u52a0\u3092\u898b\u3066\u3044\u307e\u305b\u3093\u3002\n<\/p>\n<p>\n \u3055\u3089\u306b\u3001CBD\u3068Apixaban\u3084Rivaroxaban\u306a\u3069\u306e\u7d4c\u53e3\u6297\u51dd\u56fa\u5264\u3068\u306e\u9593\u306b\u306f\u3001\u51fa\u8840\u306e\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308bCYP3A\u9175\u7d20\uff08\u304a\u3088\u3073P-GP\u6d41\u51fa\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff09\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 CBD\u304a\u3088\u3073\u3053\u308c\u3089\u306e\u85ac\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u79d1\u5b66\u6587\u732e\u306b\u8a18\u9332\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3053\u308c\u3089\u306e\u85ac\u7269\u7642\u6cd5\u3068\u5927\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u6cbb\u7642\u304c\u7c21\u5358\u306a\u51fa\u8840\u3068\u6253\u64b2\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 [4]\n<\/p>\n<p>\n \u6297\u8840\u5c0f\u677f\u85ac\u7269\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u306f\u3001CYP2C19\u3092\u4ecb\u3057\u3066\u3001\u3088\u308a\u5c11\u306a\u3044\u91cf\u3067CYP3A4\u3092\u4ecb\u3057\u3066\u305d\u306e\u6d3b\u6027\u578b\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u3068\u4e00\u7dd2\u306bCBD\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u30af\u30ed\u30d4\u30c9\u30b0\u30ec\u30eb\u306e\u6cbb\u7642\u52b9\u679c\u304c\u4f4e\u4e0b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u533b\u5e2b\u306f\u8840\u5c0f\u677f\u306e\u9069\u5207\u306a\u53cd\u5fdc\u3068\u51dd\u96c6\u3092\u30c1\u30a7\u30c3\u30af\u3059\u308b\u3053\u3068\u3092\u6c7a\u5b9a\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u7d14\u7c8b\u306b\u7406\u8ad6\u7684\u3067\u3042\u308a\u3001\u7814\u7a76\u6587\u732e\u306b\u306f\u30b1\u30fc\u30b9\u30b9\u30bf\u30c7\u30a3\u306f\u3042\u308a\u307e\u305b\u3093\u3002 [5]\n<\/p>\n<p><H2> CBD\u304a\u3088\u3073\u767a\u4f5c\u969c\u5bb3\u85ac<\/h2>\n<p>\n \u85ac\u7269\u3068CBD\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u767a\u4f5c\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u4eba\u3001\u7279\u306b\u9ad8\u7528\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306e\u9593\u3067\u4e00\u822c\u7684\u3067\u3059\u3002 CBD\u304c\u6b21\u306e\u85ac\u306eCBD\u8840\u6db2\u6fc3\u5ea6\u3068\u4f75\u305b\u3066\u6295\u4e0e\u3055\u308c\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306b\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<ul>\n<li>\n  \u30c8\u30d4\u30e9\u30e1\u30fc\u30c8\n <\/li>\n<li>\n  \u30eb\u30d5\u30a3\u30ca\u30df\u30c9\n <\/li>\n<li>\n  n-des-methylclobazam\uff08\u85ac\u7269\u30af\u30ed\u30d0\u30b6\u30e0\u306e\u6d3b\u6027\u4ee3\u8b1d\u7269\uff09\n <\/li>\n<li>\n  \u30be\u30cb\u30b5\u30df\u30c9\n <\/li>\n<li>\n  Eslicarbazepine\n <\/li>\n<p>\n  CBD\u3068\u767a\u4f5c\u85ac\u306e\u30d0\u30eb\u30d7\u30ed\u9178\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u60a3\u8005\u306f\u3001\u6f5c\u5728\u7684\u306a\u554f\u984c\u306b\u3064\u3044\u3066\u809d\u6a5f\u80fd\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\n <\/p>\n<p>   <H2> CBD\u304a\u3088\u3073\u30b9\u30bf\u30c1\u30f3\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u85ac<\/h2>\n<p>\n  \u30b9\u30bf\u30c1\u30f3\u306f\u3001\u9175\u7d20CYP3A4\u3092\u4ecb\u3057\u3066\u51e6\u7406\u3055\u308c\u308b\u305f\u3081\u3001CBD\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u6700\u3082\u4e00\u822c\u7684\u306a\u85ac\u7269\u30d5\u30a1\u30df\u30ea\u30fc\u306e1\u3064\u3067\u3059\u3002 CBD\u3068\u30b9\u30bf\u30c1\u30f3\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308a\u3001\u7406\u8ad6\u7684\u306b\u306f\u4f53\u5185\u306e\u30b9\u30bf\u30c1\u30f3\u306e\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306f\u3001CBD\u3092\u4f7f\u7528\u3057\u3066\u6cbb\u7642\u3059\u308b\u75c7\u72b6\u306b\u5178\u578b\u7684\u3067\u985e\u4f3c\u3057\u305f\u526f\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30b9\u30bf\u30c1\u30f3\u306fCBD\u3068\u306e\u4e92\u63db\u6027\u3082\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u591a\u304f\u306e\u30b9\u30bf\u30c1\u30f3\u85ac\u306f\u3001\u8a18\u61b6\u3001\u7b4b\u8089\u306e\u75db\u307f\u3001\u75b2\u52b4\u3001\u7b4b\u8089\u306e\u8870\u5f31\u306b\u95a2\u3059\u308b\u554f\u984c\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n <\/p>\n<p>\n  \u3059\u3067\u306b\u30b9\u30bf\u30c1\u30f3\u85ac\u306e\u6bce\u65e5\u306e\u6700\u5927\u6295\u4e0e\u91cf\u3092\u6442\u53d6\u3057\u3066\u3044\u308b\u6162\u6027\u75bc\u75db\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u304b\u306a\u308a\u306e\u6570\u306e\u60a3\u8005\u304c\u898b\u3089\u308c\u308b\u306e\u3067\u3001\u79c1\u306f\u3057\u3070\u3057\u3070\u533b\u5e2b\u3068\u4ee3\u66ff\u6cbb\u7642\u306b\u3064\u3044\u3066\u8a71\u3057\u5408\u3044\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306e\u6f5c\u5728\u7684\u306a\u60aa\u5f71\u97ff\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u3001\u73fe\u5728\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u30b9\u30bf\u30c1\u30f3\u306e\u6295\u4e0e\u91cf\u3092\u6e1b\u3089\u3059\u304b\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u3092\u542b\u3080\u3002\n <\/p>\n<p>   <H3> CBD\u304a\u3088\u3073\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3068\u30a2\u30be\u30fc\u30eb\u6297\u771f\u83cc<\/H3><\/p>\n<p>\n  \u6297\u751f\u7269\u8cea\u30a8\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3068\u6297\u771f\u83cc\u6027\u30a2\u30be\u30fc\u30eb\u30d5\u30a1\u30df\u30ea\u30fc\u306f\u3001CBD\u3092\u4ee3\u8b1d\u3059\u308b\u539f\u56e0\u3068\u306a\u308bCYP\u9175\u7d20\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u85ac\u7269\u3067\u3059\u3002\u305d\u308c\u3089\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3068\u3001\u7406\u8ad6\u7684\u306b\u306f\u5426\u5b9a\u7684\u306a\u7d50\u679c\u306e\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n <\/p>\n<p>   <H3> CBD\u304a\u3088\u3073\u6297\u3046\u3064\u85ac<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\n  \u3055\u307e\u3056\u307e\u306a\u6297\u3046\u3064\u85ac\u3068\u6297\u7cbe\u795e\u75c5\u85ac\u306f\u3001CBD\u3068CBD\u306b\u898b\u3089\u308c\u308b\u306e\u3068\u540c\u3058\u9175\u7d20\u3092\u4f7f\u7528\u3057\u3066\u4ee3\u8b1d\u3055\u308c\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u85ac\u7269\u3092\u670d\u7528\u3059\u308b\u3068\u3001\u60aa\u5f71\u97ff\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30a8\u30b9\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0\u307e\u305f\u306f\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0\u3068CBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b6\u4eba\u306e\u60a3\u8005\u3067\u306f\u3001CBD\uff081\u65e5\u3042\u305f\u308a200\u301c800 mg\uff09\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u8840\u6db2\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0\u30ec\u30d9\u30eb\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002\u60a3\u8005\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\u306f\u8efd\u5ea6\u3067\u3042\u308a\u3001\u4e0b\u75e2\u3001\u75b2\u52b4\u3001\u5410\u304d\u6c17\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002 [7]\n <\/p>\n<p>\n  \u3055\u3089\u306b\u3001\u4ed6\u306e\u6297\u3046\u3064\u85ac\u3068\u540c\u69d8\u306b\u3001CBD\u306f\u30bb\u30ed\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53\u3092\u5897\u52a0\u3055\u305b\u3001\u3053\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6301\u3064\u8907\u6570\u306e\u85ac\u7269\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u75c7\u5019\u7fa4\u3068\u547c\u3070\u308c\u308b\u307e\u308c\u306a\u969c\u5bb3\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u79d1\u5b66\u306e\u6587\u732e\u3067\u306f\u3001\u3053\u306e\u7a2e\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u75c7\u4f8b\u5831\u544a\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\n <\/p>\n<p>   <H3> CBD\u304a\u3088\u3073\u514d\u75ab\u6291\u5236\u85ac<\/H3><\/p>\n<p>\n  CBD\u306f\u3001\u809d\u81d3\u306e\u4ee3\u8b1d\u3092\u4ecb\u3057\u3066\u6297\u708e\u75c7\u85ac\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\u3068\u30bf\u30af\u30ed\u30ea\u30e0\u30b9\u306e\u4ee3\u8b1d\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u85ac\u7269\u306e\u8840\u6db2\u306e\u3088\u308a\u9ad8\u3044\u30ec\u30d9\u30eb\u3092\u3082\u305f\u3089\u3057\u3001\u6bd2\u6027\u526f\u526f\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 [8]\n <\/p>\n<h2><span class=\"ez-toc-section\" id=\"CBD%E3%81%8A%E3%82%88%E3%81%B3%E7%B7%91%E5%86%85%E9%9A%9C\"><\/span>\n  CBD\u304a\u3088\u3073\u7dd1\u5185\u969c<br \/>\n <span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>\n  \u7dd1\u5185\u969c\u306f\u3001\u5927\u9ebb\u3092\u533b\u5b66\u306e\u4ee3\u66ff\u3068\u898b\u306a\u3059\u3068\u304d\u306b\u8003\u3048\u308b\u50be\u5411\u304c\u3042\u308b\u4e3b\u306a\u8a3a\u65ad\u3067\u3059\u3002 THC\u306f\u3001\u6761\u4ef6\u306e\u7279\u5fb4\u3067\u3042\u308b\u4e0a\u6607\u3057\u305f\u773c\u5185\uff08\u76ee\uff09\u306e\u4e0a\u6607\uff08IOP\uff09\u3092\u4e0b\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u8a3c\u62e0\u304c\u3042\u308a\u307e\u3059\u3002\n <\/p>\n<p>\n  CBD\u306f\u75db\u307f\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u3068\u601d\u3044\u307e\u3059\u304b\uff1f\u3057\u304b\u3057\u3001\u7b54\u3048\u306f\u5b8c\u5168\u306b\u306f\u660e\u78ba\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u8a3c\u62e0\u306fCBD\u304c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\n <\/p>\n<ul>\n<li>\n   \u52d5\u7269\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u3001THC\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001CBD\u304c\u5b9f\u969b\u306b\u773c\u5185\u5727\u3092\u4e0a\u6607\u3055\u305b\u305f\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u7814\u7a76\u8005\u306f\u3001\u5727\u529b\u306e\u5897\u52a0\u306f\u3001CB1\u53d7\u5bb9\u4f53\u306b\u304a\u3051\u308bCBD\u306b\u5bfe\u3059\u308bCBD\u306e\u5f71\u97ff\u306b\u8d77\u56e0\u3059\u308b\u3068\u5224\u65ad\u3057\u307e\u3057\u305f\uff08\u9670\u6027\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u8abf\u7bc0\uff09\u3002\u540c\u3058\u7814\u7a76\u3067\u306f\u3001THC\u306e\u5f62\u3067CBD\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u3067\u3001THC\u304b\u3089\u306eIOP\u6e1b\u5c11\u306e\u5f71\u97ff\u3092\u5b8c\u5168\u306b\u9632\u3050\u3053\u3068\u304c\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002 [9]\n  <\/li>\n<li>\n   IOP\u304c\u4e0a\u6607\u3057\u305f\u4eba\u9593\u306e\u88ab\u9a13\u8005\u306e\u7814\u7a76\u306f\u300120mg\u306eCBD\u304c\u52b9\u679c\u304c\u306a\u3044\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u304c\u300140mg\u306eCBD\u306fIOP\u306e\u308f\u305a\u304b\u306a\u5897\u52a0\u3092\u3082\u305f\u3089\u3057\u305f\u3002 [10]\n  <\/li>\n<p>\n   CBD\u306b\u53cd\u3057\u3066\u3001CBDA\u306fCB1\u53d7\u5bb9\u4f53\u306eCBD\u3068\u540c\u3058CBD\u69d8\u6d3b\u6027\u3092\u6301\u3063\u3066\u3044\u306a\u3044\u305f\u3081\u3001IOP\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u3002 CB1\u53d7\u5bb9\u4f53\u3002\n  <\/p>\n<p>\n   \u7dd1\u5185\u969c\u306b\u82e6\u3057\u307f\u3001CBD\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u4f7f\u7528\u3092\u958b\u59cb\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u773c\u5727\u3092\u30c1\u30a7\u30c3\u30af\u3057\u3066CBD\u304c\u5727\u529b\u306e\u4e0a\u6607\u3092\u5f15\u304d\u8d77\u3053\u3059\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u3053\u3068\u3092\u304a\u52e7\u3081\u3057\u307e\u3059\u3002\n  <\/p>\n<p>\n   IOP\u3092\u524a\u6e1b\u3059\u308b\u305f\u3081\u306b\u5927\u9ebb\u3092\u670d\u7528\u3057\u305f\u3044\u7dd1\u5185\u969c\u60a3\u8005\u306f\u3001CBD\u304c\u4f4e\u3044THC\u512a\u5148\u88fd\u54c1\u3092\u597d\u3080\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u9ebb\u7523\u7269\u3092\u5229\u7528\u3057\u3066\u4ed6\u306e\u75c5\u6c17\u3092\u6cbb\u7642\u3057\u305f\u3044\u7dd1\u5185\u969c\u60a3\u8005\u306f\u3001CBDA\u88fd\u5264\u306e\u6069\u6075\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n  <\/p>\n<p>\n   \u3088\u304f\u5236\u5fa1\u3055\u308c\u305fIOPS\u3092\u5099\u3048\u305f\u7dd1\u5185\u969c\u60a3\u8005\u306f\u3001\u7db2\u819c\u3092\u4fdd\u8b77\u3059\u308b\u305f\u3081\u306b\u5927\u9ebb\u3092\u670d\u7528\u3057\u3088\u3046\u3068\u3057\u3066\u3044\u308b\u305f\u3081\u3001CBD\u3068THC\u3068\u306e\u7d44\u307f\u5408\u308f\u305b\u304b\u3089\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n  <\/p>\n<p>    <H2> CBD\u3092\u4f7f\u7528\u3059\u308b\u524d\u306b\u533b\u5e2b\u306b\u76f8\u8ac7\u3057\u3066\u304f\u3060\u3055\u3044<\/h2>\n<p>\n   \u8907\u6570\u306e\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u5834\u5408\u306f\u3001\u8907\u6570\u306e\u533b\u5e2b\u3092\u8a2a\u554f\u3059\u308b\u304b\u3001\u7279\u5b9a\u306e\u5065\u5eb7\u554f\u984c\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u5834\u5408\u3001\u533b\u5e2b\u306f\u3001\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u670d\u7528\u3057\u3066\u3044\u308b\u3059\u3079\u3066\u306e\u85ac\u3092\u8a8d\u8b58\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\n  <\/p>\n<p>\n   CBD\u304a\u3088\u3073\u5927\u9ebb\u306e\u4f7f\u7528\u306b\u3064\u3044\u3066\u77e5\u8b58\u306e\u3042\u308b\u533b\u5e2b\u3068\u306e\u4efb\u547d\u306f\u3001\u5426\u5b9a\u7684\u306a\u76f8\u4e92\u4f5c\u7528\u3092\u907f\u3051\u308b\u305f\u3081\u306b\u3001\u85ac\u7269\u7642\u6cd5\u3068\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u6700\u9069\u306a\u30ec\u30b8\u30e1\u30f3\u3092\u78ba\u7acb\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u7279\u5b9a\u306e\u5316\u5408\u7269\u306fCBD\u3068\u306e\u76f8\u4e57\u52b9\u679c\u3067\u50cd\u304f\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u533b\u5e2b\u306b\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u6c42\u3081\u308b\u3053\u3068\u306f\u3001\u85ac\u306e\u5229\u70b9\u3092\u6700\u5927\u5316\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\n  <\/p>\n<p>\n   \u30aa\u30f3\u30e9\u30a4\u30f3\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u30c1\u30a7\u30c3\u30ab\u30fc\u3092\u5229\u7528\u3057\u3066\u3001\u3069\u306e\u30b7\u30c8\u30af\u30ed\u30e0P450\u9175\u7d20\u304c\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u304b\u3092\u5224\u65ad\u3057\u307e\u3059\u3002 CBD\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u5834\u5408\uff08Cannabidiol\u3092\u8a8d\u8b58\u3057\u306a\u3044\u5834\u5408\u306f\u300cEpidiolex\u300d\u3068\u5165\u529b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff09\u3002\u3088\u308a\u7dbf\u5bc6\u306b\u76e3\u8996\u3057\u3001\u533b\u5e2b\u306b\u901a\u77e5\u3059\u308b\u305f\u3081\u306b\u78ba\u8a8d\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3088\u308a\u5927\u304d\u306a\u6295\u4e0e\u91cf\u3092\u3068\u308b\u3068\u3001\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u5c11\u91cf\u306f\u3001\u85ac\u7269\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u304c\u6700\u3082\u4f4e\u304f\u306a\u308a\u307e\u3059\u3002\n  <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E5%8F%82%E7%85%A7\"><\/span>\u53c2\u7167<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>   [1] Stout\u3001Stephen M.\u3001\u304a\u3088\u3073Nina M. Cimino\u3002 \u300c\u57fa\u8cea\u3001\u963b\u5bb3\u5264\u3001\u304a\u3088\u3073\u30d2\u30c8\u85ac\u7269\u4ee3\u8b1d\u9175\u7d20\u306e\u8a98\u5c0e\u8005\u3068\u3057\u3066\u306e\u5916\u56e0\u6027\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3002\u300d\u85ac\u7269\u4ee3\u8b1d\u30ec\u30d3\u30e5\u30fc46.1\uff082014\uff09\uff0886-95\uff09\u3002\n  <\/p>\n<p class = \"p8\">\n   [2] Alsherbiny\u3001Muhammad\u3001\u304a\u3088\u3073Chun Li\u3002 &#8220;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc6473892\/\" target=\"_blank\" rel=\"noopener\"> <span class =\" s6 \"> <b>\u85ac\u5264\u306e\u76f8\u4e92\u4f5c\u7528<\/b> <\/span> <\/a>\u3002\u300d\u533b\u85ac\u54c16.1\uff082019\uff09\uff1a3\u3002\n  <\/p>\n<p class = \"p8\">\n   [3]\u30b0\u30ec\u30a4\u30bd\u30f3\u3001\u30ec\u30b9\u30ea\u30fc\u4ed6&#8221;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29387536\/\" target=\"_blank\" rel=\"noopener\"> <span class =\" s6 \"> <b>\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068\u30ab\u30f3\u30ca\u30d3\u30c7\u30a3\u30aa\u30fc\u30eb\u306e\u76f8\u4e92\u4f5c\u7528\u3001\u75c7\u4f8b\u5831\u544a<\/b> < \/span> <\/a>\u3002\u300d\u3066\u3093\u304b\u3093\u3068\u884c\u52d5\u306b\u95a2\u3059\u308b\u5831\u544a9\uff082018\uff09\uff1a10\u3002\n  <\/p>\n<p class = \"p8\">\n   [4] Paduch\u3001McKenzie\u3001\u304a\u3088\u3073Angela R. Thomason\u3002 &#8220;<a href=\"https:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/0018578720985438?journalcode=hpxa\" target=\"_blank\" rel=\"noopener\"> <span class =\" s6 \"> <b>\u8a98\u5c0e\u4f53\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u3068\u305d\u306e\u8a98\u5c0e\u4f53\u3068\u306e\u9593\u306e\u6f5c\u5728\u7684\u306a\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\u6297\u51dd\u56fa\u5264<\/b> <\/span> <\/a>\u3002 &#8221; <i>\u75c5\u9662\u85ac\u5c40<\/i>\uff082021\uff09\uff1a0018578720985438\u3002\n  <\/p>\n<p class = \"p8\">\n   [5] Greger\u3001Jessica\u3001et al\u3002 &#8220;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31724188\/\" target=\"_blank\" rel=\"noopener\"> <span class =\" s6 \"> <b>\u6297\u51dd\u56fa\u5264\u304a\u3088\u3073\u6297\u51dd\u56fa\u5264\u304a\u3088\u3073\u6297\u8840\u5c0f\u677f\u5264\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u30ec\u30d3\u30e5\u30fc<\/b> <\/span> <\/a>\u3002\u300d <i> Journal of Clinical Pharmacology <\/i> 60.4\uff082020\uff09\uff1a432-438\u3002\n  <\/p>\n<p class = \"p7\">\n   [6] Gaston\u3001Tyler E.\u3001et al\u3002 \u300c\u30ab\u30f3\u30ca\u30d3\u30b8\u30aa\u30fc\u30eb\u3068\u4e00\u822c\u7684\u306b\u4f7f\u7528\u3055\u308c\u308b\u6297\u3066\u3093\u304b\u3093\u85ac\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3002\u300d\u30a8\u30d4\u30ec\u30d7\u30b7\u30a258.9\uff082017\uff09\uff1a1586-1592\u3002\n  <\/p>\n<p class = \"p7\">\n   [7] Anderson\u3001Lyndsey L.\u3001et al\u3002 \u300c\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0\u3068\u30ab\u30f3\u30ca\u30d3\u30b8\u30aa\u30fc\u30eb\uff1a\u82e5\u8005\u306e\u4e0d\u5b89\u969c\u5bb3\u306e\u6cbb\u7642\u306b\u95a2\u9023\u3059\u308b\u85ac\u7269\u52d5\u614b\u76f8\u4e92\u4f5c\u7528\u306ein vitro\u304a\u3088\u3073in vivo\u306e\u8a3c\u62e0\u3002\u300d Journal of Clinical Psychopharmacology 41.5\uff082021\uff09\uff1a525-533\u3002\n  <\/p>\n<p class = \"p8\">\n   [8] Balachandran\u3001Premalatha\u3001Mahmoud Elsohly\u3001Kevin P. Hill\u3002 &#8220;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33515191\/\" target=\"_blank\" rel=\"noopener\"> <span class =\" s6 \"> <b>\u85ac\u7269\u3001\u9055\u6cd5\u7269\u8cea\u3001\u304a\u3088\u3073\u30a2\u30eb\u30b3\u30fc\u30eb\u3068\u306e\u5927\u9ebb\u76f8\u4e92\u4f5c\u7528\uff1a\u5305\u62ec\u7684\u306a\u30ec\u30d3\u30e5\u30fc< \/b> <\/span> <\/a>\u3002 &#8221; <i> Journal of General Internal Medicine <\/i>\uff082021\uff09\uff1a1-11\u3002\n  <\/p>\n<p class = \"p8\">\n   [9]\u30df\u30e9\u30fc\u3001\u30b5\u30ea\u30fc\u3001\u4ed6&#8221;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30550613\/\" target=\"_blank\" rel=\"noopener\"> <span class =\" s6 \"> <b> d9-\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30ab\u30f3\u30ca\u30d3\u30ce\u30fc\u30eb\u304a\u3088\u3073\u30ab\u30f3\u30ca\u30d3\u30b8\u30eb\u306f\u3001\u773c\u5185\u5727\u529b<\/b> <\/b> <\/ span> <\/a>\u3002\u300d\u8abf\u67fb\u773c\u79d1\u3068\u8996\u899a\u79d1\u5b6659.15\uff082018\uff09\uff1a5904-5911\u3002\n  <\/p>\n<p class = \"p7\">\n   [10] Tomida\u3001Ileana\u3001et al\u3002 \u300c\u773c\u5727\u306b\u5bfe\u3059\u308b\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306e\u820c\u4e0b\u5857\u5e03\u306e\u52b9\u679c\uff1a\u30d1\u30a4\u30ed\u30c3\u30c8\u7814\u7a76\u3002\u300d Journal of Glaucoma 15.5\uff082006\uff09\uff1a349-353\u3002\n  <\/p>\n<\/ul>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u7a76\u3067\u306f\u3001CBD\u304c\u5b89\u5168\u306a\u7269\u8cea\u3068\u3057\u3066\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u65b0\u3057\u3044\u85ac\u3068\u540c\u69d8\u306b\u3001\u4ed6\u306e\u85ac\u7269\u3068\u5e72\u6e09\u3057\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u30ab\u30f3\u30ca\u30d3\u30b8\u30aa\u30fc\u30eb\uff08CBD\uff09\u306f\u3001\u904b\u52d5\u5f8c\u306e\u708e\u75c7\u3084\u75db\u307f\u306e\u6e1b\u5c11\u3084\u4e0d\u7720\u75c7\u306e\u7de9\u548c\u3001\u6c17\u5206\u3001\u7126\u70b9\u3001\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u51e6\u3059\u308b\u80fd\u529b\u306e\u6539\u5584\u306a\u3069\u3001\u591a\u6570\u306e\u5065\u5eb7\u4e0a\u306e\u5229\u70b9\u3092\u6301\u3064\u975e\u5e38\u306b\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u6210\u5206\u306b\u306a\u308a\u307e\u3059\u3002 CBD\u306f\u7121\u6bd2\u3067\u3042\u308a\u3001\u5bb3\u3092\u53ca\u307c\u3055\u306a\u3044\u5b89\u5168\u306a\u85ac\u7269\u3067\u3042\u308b\u3053\u3068\u304c\u591a\u6570\u306e\u7814\u7a76\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u306f\u7269\u8cea\u3067\u3082\u3042\u308a\u307e\u3059\u3002 CBD\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30ebCBD\u306f\u3001\u4e16\u754c\u4fdd\u5065\u6a5f\u95a2\uff08WHO\uff09\u306e\u3088\u3046\u306a\u4e3b\u8981\u306a\u4fdd\u5065\u6a5f\u95a2\u306b\u3088\u3063\u3066\u8a8d\u8b58\u3055\u308c\u3066\u304a\u308a\u3001\u52d5\u7269\u3068\u4eba\u9593\u306e\u4e21\u65b9\u306b\u3088\u3063\u3066\u5fcd\u5bb9\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 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[5] CBD\u304a\u3088\u3073\u767a\u4f5c\u969c\u5bb3\u85ac \u85ac\u7269\u3068CBD\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3001\u767a\u4f5c\u306b\u82e6\u3057\u3093\u3067\u3044\u308b\u4eba\u3001\u7279\u306b\u9ad8\u7528\u91cf\u306eCBD\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u4eba\u306e\u9593\u3067\u4e00\u822c\u7684\u3067\u3059\u3002 CBD\u304c\u6b21\u306e\u85ac\u306eCBD\u8840\u6db2\u6fc3\u5ea6\u3068\u4f75\u305b\u3066\u6295\u4e0e\u3055\u308c\u308b\u3068\u3001\u6b21\u306e\u3088\u3046\u306b\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u30c8\u30d4\u30e9\u30e1\u30fc\u30c8 \u30eb\u30d5\u30a3\u30ca\u30df\u30c9 n-des-methylclobazam\uff08\u85ac\u7269\u30af\u30ed\u30d0\u30b6\u30e0\u306e\u6d3b\u6027\u4ee3\u8b1d\u7269\uff09 \u30be\u30cb\u30b5\u30df\u30c9 Eslicarbazepine 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mg\uff09\u306e\u7d44\u307f\u5408\u308f\u305b\u304c\u8840\u6db2\u30b7\u30bf\u30ed\u30d7\u30e9\u30e0\u30ec\u30d9\u30eb\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u307e\u3057\u305f\u3002\u60a3\u8005\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\u306f\u8efd\u5ea6\u3067\u3042\u308a\u3001\u4e0b\u75e2\u3001\u75b2\u52b4\u3001\u5410\u304d\u6c17\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002 [7] \u3055\u3089\u306b\u3001\u4ed6\u306e\u6297\u3046\u3064\u85ac\u3068\u540c\u69d8\u306b\u3001CBD\u306f\u30bb\u30ed\u30c8\u30cb\u30f3\u53d7\u5bb9\u4f53\u3092\u5897\u52a0\u3055\u305b\u3001\u3053\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u6301\u3064\u8907\u6570\u306e\u85ac\u7269\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u75c7\u5019\u7fa4\u3068\u547c\u3070\u308c\u308b\u307e\u308c\u306a\u969c\u5bb3\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u79d1\u5b66\u306e\u6587\u732e\u3067\u306f\u3001\u3053\u306e\u7a2e\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u75c7\u4f8b\u5831\u544a\u306f\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002 CBD\u304a\u3088\u3073\u514d\u75ab\u6291\u5236\u85ac 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