{"id":118302,"date":"2022-05-22T15:30:00","date_gmt":"2022-05-22T13:30:00","guid":{"rendered":"https:\/\/hemppedia.org\/?p=118302"},"modified":"2022-05-18T10:43:33","modified_gmt":"2022-05-18T08:43:33","slug":"%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf","status":"publish","type":"post","link":"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/","title":{"rendered":"\u795e\u7d4c\u7cfb\u306b\u5bfe\u3059\u308b\u5927\u9ebb\u306e\u5f71\u97ff"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_57_1 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor: pointer\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default 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href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E3%80%8CDelta-9-Tetrahydrocannabinol%E3%81%AE%E9%8E%AE%E7%97%9B%E7%89%B9%E6%80%A7%E3%80%82%E3%80%8D\" title=\"\n \u300cDelta-9-Tetrahydrocannabinol\u306e\u93ae\u75db\u7279\u6027\u3002\u300d \n\">\n \u300cDelta-9-Tetrahydrocannabinol\u306e\u93ae\u75db\u7279\u6027\u3002\u300d \n<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E6%A6%82%E8%A6%81\" title=\"\n \u6982\u8981 \n\">\n \u6982\u8981 \n<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E8%A6%81%E7%B4%84%EF%BC%9A%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6-2\" title=\"\n  \n  \u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76 \n  \n\">\n  \n  \u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76 \n  \n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E3%80%8C%E3%83%97%E3%83%A9%E3%82%BB%E3%83%9C%E5%88%B6%E5%BE%A1%E3%81%95%E3%82%8C%E3%81%9F%E7%94%A8%E9%87%8F%E3%81%AE%E3%83%A9%E3%83%B3%E3%83%80%E3%83%A0%E5%8C%96%E3%81%95%E3%82%8C%E3%81%9F%E7%A0%94%E7%A9%B6%E3%81%A7%E6%AE%B5%E9%9A%8E%E7%9A%84%E3%81%AB%E5%88%B6%E5%BE%A1%E3%81%95%E3%82%8C%E3%81%A6%E3%81%84%E3%81%AA%E3%81%84%E6%85%A2%E6%80%A7%E7%96%BC%E7%97%9B%E3%81%AB%E8%8B%A6%E3%81%97%E3%82%80%E3%82%AA%E3%83%94%E3%82%AA%E3%82%A4%E3%83%89%E3%81%A7%E6%B2%BB%E7%99%82%E3%81%95%E3%82%8C%E3%81%9F%E7%99%8C%E6%82%A3%E8%80%85%E3%81%AE%E3%83%8A%E3%83%93%E3%82%AD%E3%82%B7%E3%83%A2%E3%83%BC%E3%83%AB%E3%80%82%E3%80%8D\" title=\"\n 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href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E6%A6%82%E8%A6%81-3\" title=\"\n \u6982\u8981 \n\">\n \u6982\u8981 \n<\/a><ul class='ez-toc-list-level-4'><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E7%9B%AE%E7%9A%84%EF%BC%9A\" title=\"\n \u76ee\u7684\uff1a \n\">\n \u76ee\u7684\uff1a \n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E6%96%B9%E6%B3%95%EF%BC%9A\" title=\"\n \u65b9\u6cd5\uff1a \n\">\n \u65b9\u6cd5\uff1a \n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a 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\u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76 \n  \n\">\n  \n  \u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76 \n  \n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E3%80%8C%E3%82%AB%E3%83%B3%E3%83%8A%E3%83%93%E3%83%8E%E3%82%A4%E3%83%89%E3%81%A8%E8%84%B3%E6%90%8D%E5%82%B7%E3%81%AE%E6%B2%BB%E7%99%82%E7%9A%84%E6%84%8F%E5%91%B3%E3%80%82%E3%80%8D\" title=\"\n \u300c\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u3068\u8133\u640d\u50b7\u306e\u6cbb\u7642\u7684\u610f\u5473\u3002\u300d \n\">\n \u300c\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u3068\u8133\u640d\u50b7\u306e\u6cbb\u7642\u7684\u610f\u5473\u3002\u300d \n<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E6%A6%82%E8%A6%81-4\" title=\"\n \u6982\u8981 \n\">\n \u6982\u8981 \n<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E8%A6%81%E7%B4%84%EF%BC%9A%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6-5\" title=\"\n  \n  \u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76 \n  \n\">\n  \n  \u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76 \n  \n<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E5%A4%A7%E9%BA%BB%E3%81%AE%E4%BD%BF%E7%94%A8%E5%BE%8C%E3%81%AE%E8%87%AA%E5%8B%95%E8%BB%8A%E4%BA%8B%E6%95%85%E3%81%AE%E3%80%8C%E7%94%A8%E9%87%8F%E9%96%A2%E9%80%A3%E3%81%AE%E3%83%AA%E3%82%B9%E3%82%AF%E3%80%8D%E3%80%82\" title=\"\n \u5927\u9ebb\u306e\u4f7f\u7528\u5f8c\u306e\u81ea\u52d5\u8eca\u4e8b\u6545\u306e\u300c\u7528\u91cf\u95a2\u9023\u306e\u30ea\u30b9\u30af\u300d\u3002 \n\">\n \u5927\u9ebb\u306e\u4f7f\u7528\u5f8c\u306e\u81ea\u52d5\u8eca\u4e8b\u6545\u306e\u300c\u7528\u91cf\u95a2\u9023\u306e\u30ea\u30b9\u30af\u300d\u3002 \n<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/old.hemppedia.org\/ja\/%e7%a5%9e%e7%b5%8c%e7%b3%bb%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%a4%a7%e9%ba%bb%e3%81%ae%e5%bd%b1%e9%9f%bf\/#%E6%A6%82%E8%A6%81-5\" title=\"\n \u6982\u8981 \n\">\n \u6982\u8981 \n<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-top\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;118302&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;top&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;1&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;5&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;4&quot;,&quot;greet&quot;:&quot;Rate post&quot;,&quot;legend&quot;:&quot;5\\\/5 - (1)&quot;,&quot;size&quot;:&quot;20&quot;,&quot;title&quot;:&quot;\\u795e\\u7d4c\\u7cfb\\u306b\\u5bfe\\u3059\\u308b\\u5927\\u9ebb\\u306e\\u5f71\\u97ff&quot;,&quot;width&quot;:&quot;118&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 118px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 16px;\">\n            5\/5 - (1)    <\/div>\n    <\/div>\n<p>\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u3001\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u3001\u708e\u75c7\u75db\u3001\u764c\u306e\u75db\u307f\u3092\u542b\u3080\u75db\u307f\u306e\u91cd\u75c7\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u3001\u7b4b\u8089\u306e\u75d9\u6523\u306b\u4f34\u3046\u4e0d\u5feb\u611f\u3060\u3051\u3067\u306a\u304f\u3001\u75d9\u7e2e\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u75db\u307f\u306e\u91cd\u75c7\u5ea6\u3092\u6e1b\u3089\u3059\u3053\u3068\u306b\u52a0\u3048\u3066\u3001\u591a\u304f\u306e\u60a3\u8005\u306f\u3001\u5927\u9ebb\u304c\u75db\u307f\u304c\u611f\u3058\u3089\u308c\u308b\u65b9\u6cd5\u3092\u5909\u3048\u308b\u3068\u8a00\u3044\u3001\u6c17\u3092\u6563\u3089\u3059\u3060\u3051\u3067\u306a\u304f\u75db\u307f\u3092\u8efd\u6e1b\u3057\u307e\u3059\u3002\u72b6\u6cc1\u306b\u3088\u3063\u3066\u306f\u3001\u5927\u9ebb\u304c\u6025\u6027\u306e\u75db\u307f\u306e\u5f37\u5ea6\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u3088\u3046\u306a\u6162\u6027\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u75be\u60a3\u304b\u3089\u3060\u3051\u3067\u306a\u304f\u3001\u982d\u90e8\u5916\u50b7\u3084\u8133\u5352\u4e2d\u306a\u3069\u306e\u6025\u6027\u640d\u50b7\u304b\u3089\u795e\u7d4c\u3092\u4fdd\u8b77\u3059\u308b\u795e\u7d4c\u4fdd\u8b77\u6027\u3067\u3059\u3002\u5f7c\u3089\u306f\u307e\u305f\u3001\u6297\u3051\u3044\u308c\u3093\u7279\u6027\u3092\u6301\u3063\u3066\u304a\u308a\u3001\u7279\u5b9a\u306e\u72b6\u6cc1\u3067\u306f\u6297\u7cbe\u795e\u75c5\u85ac\u3082\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<p>\n \u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u3001\u795e\u7d4c\u7cfb\u3092\u901a\u3058\u3066\u610f\u8b58\u3092\u5909\u3048\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002\u6fc3\u5ea6\u307e\u305f\u306f\u8abf\u88fd\u306b\u57fa\u3065\u3044\u3066\u3001\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u523a\u6fc0\u307e\u305f\u306f\u30ea\u30e9\u30c3\u30af\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u3001\u53cd\u5fdc\u306e\u901f\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u611f\u899a\u306e\u77e5\u899a\u306b\u304a\u3051\u308b\u4ed6\u306e\u4fee\u98fe\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u591a\u304f\u306e\u60a3\u8005\u306f\u3001\u5927\u9ebb\u306e\u4f7f\u7528\u5f8c\u306b\u3001\u30dd\u30b8\u30c6\u30a3\u30d6\u306a\u6c17\u5206\u3068\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u3001\u7b11\u3044\u58f0\u3068\u793e\u4f1a\u7684\u5feb\u9069\u3055\u3001\u6642\u9593\u306e\u6b6a\u307f\u3001\u65e5\u5e38\u30a4\u30d9\u30f3\u30c8\u306e\u5f37\u5ea6\uff08\u98df\u4e8b\u3001\u6027\u7684\u6d3b\u52d5\u3001\u97f3\u697d\u3092\u8074\u304f\uff09\u306e\u5897\u52a0\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 \u3002\u5927\u9ebb\u306f\u3001\u89e3\u96e2\u306e\u52b9\u679c\uff08\u81ea\u5206\u306e\u4f53\u3068\u5468\u56f2\u304b\u3089\u306e\u610f\u8b58\u304c\u5207\u65ad\u3055\u308c\u308b\uff09\u3068\u3001\u7d71\u5408\u7d50\u679c\uff08\u81ea\u5206\u81ea\u8eab\u3068\u74b0\u5883\u306e\u3088\u308a\u5927\u304d\u306a\u8a8d\u8b58\uff09\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%A6%81%E7%B4%84%EF%BC%9A%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6\"><\/span>\n  <strong>\u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76<\/strong> <span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h2><span class=\"ez-toc-section\" id=\"%E3%80%8CDelta-9-Tetrahydrocannabinol%E3%81%AE%E9%8E%AE%E7%97%9B%E7%89%B9%E6%80%A7%E3%80%82%E3%80%8D\"><\/span>\n \u300cDelta-9-Tetrahydrocannabinol\u306e\u93ae\u75db\u7279\u6027\u3002\u300d<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/50159\" target=\"_blank\" noopener rel=\"noopener\"> noyes r jr\u3001brunk sf\u3001avery da\u3001canter ac \u3002<\/a><br \/>\n <\/a>\n<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81\"><\/span>\n \u6982\u8981<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\n \u764c\u75bc\u75db\u60a3\u8005\u3078\u306e\u30c7\u30eb\u30bf-9-\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30ab\u30f3\u30ca\u30d3\u30ce\u30fc\u30eb\uff08THC\uff09\u306e\u5358\u4e00\u7d4c\u53e3\u6295\u4e0e\u306e\u6295\u4e0e\u306f\u3001\u8efd\u5ea6\u306e\u93ae\u75db\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002 20 mg\u306e\u7528\u91cf\u3067\u306f\u3001THC\u306f\u526f\u4f5c\u7528\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u3081\u307e\u3044\u3001\u50be\u659c\u3001\u904b\u52d5\u5931\u8abf\u75c7\u3001\u904b\u52d5\u5931\u8abf\u306a\u3069\u306e\u6cbb\u7642\u76ee\u7684\u3067\u306e\u4f7f\u7528\u3092\u59a8\u3052\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u6295\u4e0e\u6642\u306b\u3082\u4e88\u671f\u3057\u306a\u3044\u526f\u4f5c\u7528\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002 THC 10 mg\u306f\u5fcd\u5bb9\u6027\u304c\u9ad8\u304f\u3001\u93ae\u9759\u52b9\u679c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u93ae\u75db\u52b9\u679c\u304c\u3042\u308a\u307e\u3059\u3002\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%A6%81%E7%B4%84%EF%BC%9A%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6-2\"><\/span>\n <strong><br \/>\n  <strong>\u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76<\/strong><br \/>\n <\/strong><br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h2><span class=\"ez-toc-section\" id=\"%E3%80%8C%E3%83%97%E3%83%A9%E3%82%BB%E3%83%9C%E5%88%B6%E5%BE%A1%E3%81%95%E3%82%8C%E3%81%9F%E7%94%A8%E9%87%8F%E3%81%AE%E3%83%A9%E3%83%B3%E3%83%80%E3%83%A0%E5%8C%96%E3%81%95%E3%82%8C%E3%81%9F%E7%A0%94%E7%A9%B6%E3%81%A7%E6%AE%B5%E9%9A%8E%E7%9A%84%E3%81%AB%E5%88%B6%E5%BE%A1%E3%81%95%E3%82%8C%E3%81%A6%E3%81%84%E3%81%AA%E3%81%84%E6%85%A2%E6%80%A7%E7%96%BC%E7%97%9B%E3%81%AB%E8%8B%A6%E3%81%97%E3%82%80%E3%82%AA%E3%83%94%E3%82%AA%E3%82%A4%E3%83%89%E3%81%A7%E6%B2%BB%E7%99%82%E3%81%95%E3%82%8C%E3%81%9F%E7%99%8C%E6%82%A3%E8%80%85%E3%81%AE%E3%83%8A%E3%83%93%E3%82%AD%E3%82%B7%E3%83%A2%E3%83%BC%E3%83%AB%E3%80%82%E3%80%8D\"><\/span>\n \u300c\u30d7\u30e9\u30bb\u30dc\u5236\u5fa1\u3055\u308c\u305f\u7528\u91cf\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u3055\u308c\u305f\u7814\u7a76\u3067\u6bb5\u968e\u7684\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u306a\u3044\u6162\u6027\u75bc\u75db\u306b\u82e6\u3057\u3080\u30aa\u30d4\u30aa\u30a4\u30c9\u3067\u6cbb\u7642\u3055\u308c\u305f\u764c\u60a3\u8005\u306e\u30ca\u30d3\u30ad\u30b7\u30e2\u30fc\u30eb\u3002\u300d<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81-2\"><\/span>\n \u6982\u8981<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22483680\" rel=\"noopener noreferrer\" target=\"_blank\"> Portenoy\u3001Russell K.\u306a\u3069><br \/>\n <\/a>\n<\/p>\n<p>\n \u30aa\u30d4\u30aa\u30a4\u30c9\u7642\u6cd5\u306b\u53cd\u5fdc\u3057\u306a\u3044\u75c7\u72b6\u3092\u7d4c\u9a13\u3059\u308b\u9032\u884c\u304c\u3093\u306b\u82e6\u3057\u3080\u60a3\u8005\u306f\u3001\u81e8\u5e8a\u7814\u7a76\u306e\u554f\u984c\u3092\u63d0\u793a\u3057\u307e\u3059\u3002 Nabiximols\uff08Nabiximols\u306f\u3001Sativex\uff08GW Pharma Limited\u3002\u3001Wiltshire\u3001U.K\u3002]\u306e\u7c73\u56fd\u63a1\u7528\u540d[Usan]\u3067\u3059\u3002\u3053\u308c\u306f\u307e\u3060\u5bbf\u5c4b\u3092\u6240\u6709\u3057\u3066\u3044\u307e\u305b\u3093\uff09\u65b0\u3057\u3044\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u30d9\u30fc\u30b9\u306e\u88fd\u5264\u306f\u3001\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u8ffd\u52a0\u6cbb\u7642\u3068\u3057\u3066\u7814\u7a76\u4e2d\u3067\u3059\u3002\u60a3\u8005\u3002\u30aa\u30d4\u30aa\u30a4\u30c9\u62b5\u6297\u6027\u306e\u9032\u884c\u304c\u3093\u3084\u75db\u307f\u306b\u82e6\u3057\u3080\u6bb5\u968e\u7684\u7528\u91cf\u60a3\u8005\u306e\u30d7\u30e9\u30bb\u30dc\u306b\u3088\u3063\u3066\u5bfe\u7167\u3055\u308c\u305f\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u7814\u7a76\u3067\u306f\u3001\u4f4e\u7528\u91cf\uff081\u65e5\u3042\u305f\u308a1\u301c4\u30b9\u30d7\u30ec\u30fc\uff09\u3067\u30ca\u30d3\u30ad\u30b7\u30e2\u30fc\u30eb\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3067\u6cbb\u7642\u3055\u308c\u307e\u3057\u305f\u3002\u4e2d\u7a0b\u5ea6\u306e\u6295\u4e0e\u91cf\uff086\u301c10\u30b9\u30d7\u30ec\u30fc\/\u65e5\uff09\u307e\u305f\u306f\u6700\u9ad8\u7528\u91cf\uff0811\u301c16\u30b9\u30d7\u30ec\u30fc\/\u65e5\uff09\u3002\u5e73\u5747\u75db\u307f\u3001\u6700\u3082\u6fc0\u3057\u3044\u75db\u307f\u3068\u7761\u7720\u969c\u5bb3\u306f5\u9031\u9593\u306e\u6cbb\u7642\u3067\u6bce\u65e5\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u751f\u547d\u3068\u6c17\u5206\u3002\u5408\u8a08360\u4eba\u306e\u60a3\u8005\u304c\u30e9\u30f3\u30c0\u30e0\u306b\u5272\u308a\u5f53\u3066\u3089\u308c\u307e\u3057\u305f\u3002263\u4eba\u304c\u7814\u7a76\u3092\u5b8c\u4e86\u3057\u307e\u3057\u305f\u3002\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306b\u5dee\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u521d\u671f\u5206\u6790\u306e30\uff05\u306e\u53cd\u5fdc\u7387\u306f\u3001Nabiximols\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3067\u306f\u6709\u610f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u5168\u4f53\u306ep =\u3002 59\uff09\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u7814\u7a76\u306e\u7d42\u308f\u308a\u307e\u3067\u306e\u5e73\u57471\u65e5\u306e\u75db\u307f\u30ec\u30d9\u30eb\u306f\u3001\u93ae\u75db\u3092\u5831\u544a\u3057\u305f\u60a3\u8005\u306e\u5272\u5408\u306f\u3001\u7279\u306b\u4e2d\u7a0b\u5ea6\u306e\u6295\u4e0e\uff08P\u7b49\u3057\u3044.008\uff09\u3067\u7279\u306b\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u30ca\u30d3\u30ad\u30b7\u30e2\u30fc\u30eb\u306e\u5272\u5408\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\uff08P.035\uff09\u4e2d\u7a0b\u5ea6\u306e\u7528\u91cf\uff08p\u306b\u7b49\u3057\u3044\uff09\u30b0\u30eb\u30fc\u30d7\u3002\u4f4e\u7528\u91cf\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u4e0d\u5feb\u611f\u306e\u5e73\u5747\uff08p\u306f.006\uff09\u306b\u5339\u6575\u3057\u3001\u5e73\u5747\u306e\u6700\u3082\u91cd\u5ea6\u306e\u4e0d\u5feb\u611f\uff08p\u306f.011\uff09\u3068\u5e73\u5747\u7761\u7720\u969c\u5bb3\uff08P\u7b49\u3057\u3044.003\uff09\u3067\u3057\u305f\u3002\u4ed6\u306e\u30a2\u30f3\u30b1\u30fc\u30c8\u306f\u3001\u6709\u610f\u306a\u30b0\u30eb\u30fc\u30d7\u306e\u9055\u3044\u3092\u793a\u3055\u306a\u304b\u3063\u305f\u3002\u6709\u5bb3\u4e8b\u8c61\u306f\u7528\u91cf\u95a2\u9023\u3067\u3042\u308a\u3001\u9ad8\u7528\u91cf\u7fa4\u306e\u307f\u304c\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u6bd4\u8f03\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u4f4e\u7528\u91cf\u3067\u306e\u30ca\u30d3\u30ad\u30b7\u30e2\u30fc\u30eb\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u78ba\u8a8d\u3057\u3001\u5c06\u6765\u306e\u8a66\u9a13\u306b\u91cd\u8981\u306a\u7528\u91cf\u30c7\u30fc\u30bf\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\n<\/p>\n<h4><span class=\"ez-toc-section\" id=\"%E8%A6%96%E7%82%B9%EF%BC%9A\"><\/span>\n \u8996\u70b9\uff1a<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>\n \u65b0\u3057\u3044\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u30d9\u30fc\u30b9\u306e\u88fd\u5264\u3067\u3042\u308bNabiximols\u306f\u3001\u30aa\u30d4\u30aa\u30a4\u30c9\u8010\u6027\u75bc\u75db\u306b\u82e6\u3057\u3080\u304c\u3093\u60a3\u8005\u306e\u93ae\u75db\u85ac\u3078\u306e\u52b9\u679c\u7684\u306a\u8ffd\u52a0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u6bb5\u968e\u7684\u7528\u91cf\u306e\u30d7\u30e9\u30bb\u30dc\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u305f\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u7814\u7a76\u306f\u3001\u4e2d\u7a0b\u5ea6\u304a\u3088\u3073\u4f4e\u7528\u91cf\u3067\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u8a3c\u660e\u3057\u307e\u3057\u305f\u3002\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%A6%81%E7%B4%84%EF%BC%9A%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6-3\"><\/span>\n <strong><br \/>\n  <strong>\u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76<\/strong><br \/>\n <\/strong><br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h2><span class=\"ez-toc-section\" id=\"%E3%80%8C%E7%B3%BB%E7%B5%B1%E7%9A%84%E3%83%AC%E3%83%93%E3%83%A5%E3%83%BC%EF%BC%9A%E7%89%B9%E5%AE%9A%E3%81%AE%E7%A5%9E%E7%B5%8C%E9%9A%9C%E5%AE%B3%E3%81%AB%E3%81%8A%E3%81%91%E3%82%8B%E5%8C%BB%E7%99%82%E7%94%A8%E3%83%9E%E3%83%AA%E3%83%95%E3%82%A1%E3%83%8A%E3%81%AE%E6%9C%89%E5%8A%B9%E6%80%A7%E3%81%A8%E3%82%BB%E3%82%AD%E3%83%A5%E3%83%AA%E3%83%86%E3%82%A3%EF%BC%9A%E3%82%A2%E3%83%A1%E3%83%AA%E3%82%AB%E7%A5%9E%E7%B5%8C%E5%AD%A6%E4%BC%9A%E3%81%AE%E3%82%AC%E3%82%A4%E3%83%89%E3%83%A9%E3%82%A4%E3%83%B3%E9%96%8B%E7%99%BA%E5%B0%8F%E5%A7%94%E5%93%A1%E4%BC%9A%E3%81%AE%E5%A0%B1%E5%91%8A%E3%80%82%E3%80%8D\"><\/span>\n \u300c\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\uff1a\u7279\u5b9a\u306e\u795e\u7d4c\u969c\u5bb3\u306b\u304a\u3051\u308b\u533b\u7642\u7528\u30de\u30ea\u30d5\u30a1\u30ca\u306e\u6709\u52b9\u6027\u3068\u30bb\u30ad\u30e5\u30ea\u30c6\u30a3\uff1a\u30a2\u30e1\u30ea\u30ab\u795e\u7d4c\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u958b\u767a\u5c0f\u59d4\u54e1\u4f1a\u306e\u5831\u544a\u3002\u300d<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24778283\" rel=\"noopener noreferrer\" target=\"_blank\" ><br \/>\n <\/a>\n<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81-3\"><\/span>\n \u6982\u8981<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h4><span class=\"ez-toc-section\" id=\"%E7%9B%AE%E7%9A%84%EF%BC%9A\"><\/span>\n \u76ee\u7684\uff1a<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>\n \u3055\u307e\u3056\u307e\u306a\u795e\u7d4c\u5b66\u7684\u72b6\u614b\u306b\u5bfe\u3059\u308b\u533b\u7642\u7528\u30de\u30ea\u30d5\u30a1\u30ca\u306e\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3002\n<\/p>\n<h4><span class=\"ez-toc-section\" id=\"%E6%96%B9%E6%B3%95%EF%BC%9A\"><\/span>\n \u65b9\u6cd5\uff1a<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>\n MS\uff08MS\uff09\u3066\u3093\u304b\u3093\u306e\u75c7\u72b6\u3084\u305d\u306e\u4ed6\u306e\u904b\u52d5\u969c\u5bb3\u306e\u75c7\u72b6\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b\u3001\u533b\u7642\u5927\u9ebb\uff081948\u5e7411\u6708\uff09\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u6cbb\u7642\u7684\u306a\u8a18\u4e8b\u306b\u3064\u3044\u3066\u3001\u30a2\u30e1\u30ea\u30ab\u795e\u7d4c\u5b66\u4f1a\u5206\u985e\u30b7\u30b9\u30c6\u30e0\u306b\u5f93\u3063\u3066\u7814\u7a76\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\n<\/p>\n<h4><span class=\"ez-toc-section\" id=\"%E7%B5%90%E6%9E%9C%EF%BC%9A\"><\/span>\n \u7d50\u679c\uff1a<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>\n \u7814\u7a76\u306e34\u304c\u9078\u629e\u57fa\u6e96\u3092\u6e80\u305f\u3057\u307e\u3057\u305f\u3002\u30af\u30e9\u30b9I\u306b8\u3064\u306e\u7814\u7a76\u304c\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002\n<\/p>\n<h4><span class=\"ez-toc-section\" id=\"%E7%B5%90%E8%AB%96%EF%BC%9A\"><\/span>\n \u7d50\u8ad6\uff1a<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h4>\n<p>\n MS\u306b\u82e6\u3057\u3080\u60a3\u8005\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u554f\u984c\u304c\u8abf\u67fb\u3055\u308c\u307e\u3057\u305f\u3002\uff081\uff09\u75d9\u7e2e\u307e\u305f\u306f\u7d4c\u53e3\u5927\u9ebb\u62bd\u51fa\u7269\uff08OCE\uff09\u306f\u30ca\u30d3\u30ad\u30b7\u30e2\u30fc\u30eb\u3068\u540c\u69d8\u306b\u975e\u5e38\u306b\u52b9\u679c\u7684\u3067\u3042\u308a\u3001\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30ab\u30f3\u30ca\uff08THC\uff09\u306f\u60a3\u8005\u4e2d\u5fc3\u306e\u6e2c\u5b9a\u5024\u3092\u6e1b\u3089\u3059\u306e\u306b\u52b9\u7387\u7684\u3067\u3042\u308a\u3001\u53ef\u80fd\u3067\u3059\u3002 OCE\u3068THC\u306e\u4e21\u65b9\u304c\u30011\u5e74\u5f8c\u306b\u76ee\u7684\u3068\u60a3\u8005\u4e2d\u5fc3\u306e\u4e21\u65b9\u306e\u6e2c\u5b9a\u5024\u3092\u6e1b\u3089\u3059\u306e\u306b\u52b9\u679c\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \uff082\uff09\u75db\u307f\u3092\u5f15\u304d\u8d77\u3053\u3059\u4e2d\u5fc3\u7684\u306a\u75db\u307f\u307e\u305f\u306f\u3051\u3044\u308c\u3093\uff08\u795e\u7d4c\u969c\u5bb3\u6027\u306e\u75db\u307f\u3067\u306f\u306a\u304f\u3001\u75d9\u7e2e\u95a2\u9023\u306e\u75db\u307f\u3092\u542b\u3080\uff09OCE\u306f\u52b9\u7387\u7684\u3067\u3059\u3002 THC\u304a\u3088\u3073Nabiximols\u306f\u52b9\u7387\u7684\u3067\u3059\u3002 \uff083\uff09\u5c3f\u969c\u5bb3\uff1a\u30ca\u30d3\u30ad\u30b7\u30e2\u30fc\u30eb\u306f\u3001\u8180\u80f1\u3092\u7121\u52b9\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u56de\u6570\u3092\u6e1b\u3089\u3059\u306e\u306b\u52b9\u7387\u7684\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 THC\u3068OCE\u306f\u3001\u8180\u80f1\u306e\u554f\u984c\u306e\u6e1b\u5c11\u306b\u52b9\u679c\u304c\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \uff084\uff09\u632f\u6226\uff1aTHC\u3068OCE\u306f\u52b9\u679c\u304c\u306a\u3044\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u30ca\u30d3\u30ad\u30b7\u30e2\u30fc\u30eb\u306f\u52b9\u679c\u7684\u3067\u306f\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \uff085\uff09\u4ed6\u306e\u795e\u7d4c\u969c\u5bb3OCE\u306f\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306b\u82e6\u3057\u3080\u60a3\u8005\u306e\u30ec\u30dc\u30c9\u30d1\u8a98\u767a\u6027\u30b8\u30b9\u30ad\u30cd\u30b7\u30a2\u3092\u6cbb\u7642\u3059\u308b\u306e\u306b\u52b9\u679c\u304c\u306a\u3044\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002\u7d4c\u53e3\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75be\u60a3\u3001\u30c8\u30a5\u30ec\u30c3\u30c8\u75c7\u5019\u7fa4\u3001\u5b50\u5bae\u9838\u90e8\u30b8\u30b9\u30c8\u30cb\u30a2\u3001\u3066\u3093\u304b\u3093\u306a\u3069\u306e\u975e\u8108\u7d61\u75c7\u95a2\u9023\u75c7\u72b6\u306e\u6cbb\u7642\u306b\u6709\u52b9\u6027\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u533b\u7642\u7528\u30de\u30ea\u30d5\u30a1\u30ca\u306e\u5229\u70b9\u3068\u30ea\u30b9\u30af\u3092\u614e\u91cd\u306b\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u6df1\u523b\u306a\u7cbe\u795e\u75c5\u7406\u5b66\u7684\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u30ea\u30b9\u30af\u306f1\u30d1\u30fc\u30bb\u30f3\u30c8\u306b\u8fd1\u304b\u3063\u305f\u3002\u85ac\u7528\u30de\u30ea\u30d5\u30a1\u30ca\u5bfe\u6bd4\u8f03\u52b9\u679c\u3002\u3053\u308c\u3089\u306e\u6761\u4ef6\u3067\u306f\u3001\u4ed6\u306e\u6cbb\u7642\u6cd5\u306f\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%A6%81%E7%B4%84%EF%BC%9A%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6-4\"><\/span>\n <strong><br \/>\n  <strong>\u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76<\/strong><br \/>\n <\/strong><br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h2><span class=\"ez-toc-section\" id=\"%E3%80%8C%E3%82%AB%E3%83%B3%E3%83%8A%E3%83%93%E3%83%8E%E3%82%A4%E3%83%89%E3%81%A8%E8%84%B3%E6%90%8D%E5%82%B7%E3%81%AE%E6%B2%BB%E7%99%82%E7%9A%84%E6%84%8F%E5%91%B3%E3%80%82%E3%80%8D\"><\/span>\n \u300c\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u3068\u8133\u640d\u50b7\u306e\u6cbb\u7642\u7684\u610f\u5473\u3002\u300d<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11815270\" rel=\"noopener noreferrer\" target=\"_blank\" a><br \/>\n <\/a>\n<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81-4\"><\/span>\n \u6982\u8981<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\n in vitro\u304a\u3088\u3073in vivo\u306e\u7814\u7a76\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u5408\u6210\u304a\u3088\u3073\u690d\u7269\u306e\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306e\u3088\u3046\u306b\u3001\u30a8\u30f3\u30c9\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u3001\u30a2\u30ca\u30f3\u30c0\u30df\u30c9\u304a\u3088\u30732-\u30a2\u30e9\u30ad\u30c9\u30ce\u30a4\u30eb &#8211; \u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u304c\u8133\u640d\u50b7\u5f8c\u306e\u795e\u7d4c\u4fdd\u8b77\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u53d7\u5bb9\u4f53\u30a2\u30b4\u30cb\u30b9\u30c8\u306f\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u4f5c\u52d5\u6027\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u3092\u30d6\u30ed\u30c3\u30af\u3057\u3001\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u30a2\u30eb\u30d5\u30a1\u3068\u53cd\u5fdc\u6027\u9178\u7d20\u4e2d\u9593\u4f53\u306e\u5f62\u6210\u3092\u6e1b\u5c11\u3055\u305b\u307e\u3059\u3002\u3053\u308c\u3089\u306f\u795e\u7d4c\u640d\u50b7\u306e\u4e3b\u306a\u539f\u56e0\u3067\u3059\u3002\u30a2\u30ca\u30f3\u30c0\u30df\u30c9\u30682-\u30a2\u30e9\u30ad\u30c9\u30ce\u30a4\u30eb &#8211; \u30b0\u30ea\u30bb\u30ed\u30fc\u30eb\u30a8\u30f3\u30c9\u30c3\u30af\u306e\u7523\u751f\u306f\u3001\u8133\u5916\u50b7\u5f8c\u306b\u5927\u5e45\u306b\u5897\u52a0\u3057\u3001\u3053\u308c\u3089\u306e\u7269\u8cea\u304c\u4e8c\u6b21\u640d\u50b7\u3092\u6e1b\u3089\u3059\u306e\u306b\u5f79\u7acb\u3064\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u8a3c\u62e0\u304c\u3042\u308a\u307e\u3059\u3002\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306e\u53d7\u5bb9\u4f53\u306b\u63a5\u7d9a\u3057\u306a\u3044\u7279\u5b9a\u306e\u5408\u6210\u304a\u3088\u3073\u690d\u7269\u306e\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306f\u3001\u304a\u305d\u3089\u304f\u8208\u596e\u6027\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u7d4c\u8def\u306b\u5bfe\u3059\u308b\u76f4\u63a5\u7684\u306a\u4f5c\u7528\u307e\u305f\u306f\u6297\u9178\u5316\u7269\u8cea\u3068\u3057\u3066\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u3082\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%E8%A6%81%E7%B4%84%EF%BC%9A%E5%8C%BB%E5%AD%A6%E7%A0%94%E7%A9%B6-5\"><\/span>\n <strong><br \/>\n  <strong>\u8981\u7d04\uff1a\u533b\u5b66\u7814\u7a76<\/strong><br \/>\n <\/strong><br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h2><span class=\"ez-toc-section\" id=\"%E5%A4%A7%E9%BA%BB%E3%81%AE%E4%BD%BF%E7%94%A8%E5%BE%8C%E3%81%AE%E8%87%AA%E5%8B%95%E8%BB%8A%E4%BA%8B%E6%95%85%E3%81%AE%E3%80%8C%E7%94%A8%E9%87%8F%E9%96%A2%E9%80%A3%E3%81%AE%E3%83%AA%E3%82%B9%E3%82%AF%E3%80%8D%E3%80%82\"><\/span>\n \u5927\u9ebb\u306e\u4f7f\u7528\u5f8c\u306e\u81ea\u52d5\u8eca\u4e8b\u6545\u306e\u300c\u7528\u91cf\u95a2\u9023\u306e\u30ea\u30b9\u30af\u300d\u3002<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p> <a target=\"_blank\" rel=\"noopener\"> Ramaekers\u3001Johannes G.\u306a\u3069\u3002 ><br \/>\n <\/a>\n<\/p>\n<h3><span class=\"ez-toc-section\" id=\"%E6%A6%82%E8%A6%81-5\"><\/span>\n \u6982\u8981<br \/>\n<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>\n \u30c9\u30e9\u30a4\u30d0\u30fc\u969c\u5bb3\u304a\u3088\u3073\u81ea\u52d5\u8eca\u4e8b\u6545\u306b\u304a\u3051\u308b\u30c7\u30eb\u30bf\uff089\uff09 &#8211; \u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30ab\u30f3\u30ca\u30d3\u30ce\u30fc\u30eb\uff08THC\uff09\u306e\u5f79\u5272\u306f\u3001\u5b9f\u9a13\u7684\u304a\u3088\u3073\u75ab\u5b66\u7814\u7a76\u3067\u4f1d\u7d71\u7684\u306b\u78ba\u7acb\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u7814\u7a76\u306f\u3001THC\u304c\u8a8d\u77e5\u3001\u7cbe\u795e\u904b\u52d5\u6a5f\u80fd\u3001\u304a\u3088\u3073\u7528\u91cf\u95a2\u9023\u306e\u65b9\u6cd5\u3067\u30c9\u30e9\u30a4\u30d0\u30fc\u306e\u5b9f\u969b\u306e\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u7e70\u308a\u8fd4\u3057\u5b9f\u8a3c\u3057\u3066\u3044\u307e\u3059\u3002\u6700\u5927300\u30de\u30a4\u30af\u30ed\u30b0\u30e9\u30e0\/kg THC\u306e\u5b9f\u9a13\u7528\u91cf\u306e\u7814\u7a76\u3067\u89b3\u5bdf\u3055\u308c\u305f\u969c\u5bb3\u306e\u30ec\u30d9\u30eb\u306f\u3001\u8840\u4e2d\u30a2\u30eb\u30b3\u30fc\u30eb\u30ec\u30d9\u30eb\uff08BAC\uff09>\/= 0.05 mg\/dL\u3092\u5f15\u304d\u8d77\u3053\u3059\u30a2\u30eb\u30b3\u30fc\u30eb\u6295\u4e0e\u91cf\u306e\u969c\u5bb3\u52b9\u679c\u306b\u5339\u6575\u3057\u307e\u3057\u305f\u3002\u591a\u304f\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u8af8\u56fd\u3067\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u308b\u9593\u3001\u904b\u8ee2\u306e\u5236\u9650\u3002 THC\u306e\u9ad8\u7528\u91cf\u3001\u3064\u307e\u308a300\u30de\u30a4\u30af\u30ed\u30b0\u30e9\u30e0\/kg THC\u306f\u3001\u8a73\u7d30\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3088\u308a\u591a\u304f\u306e\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u4e88\u60f3\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 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