{"id":85463,"date":"2020-01-14T11:41:30","date_gmt":"2020-01-14T10:41:30","guid":{"rendered":"https:\/\/hemppedia.org\/cbd-i-celiakia\/"},"modified":"2021-10-28T17:15:00","modified_gmt":"2021-10-28T15:15:00","slug":"cbd-i-celiakia","status":"publish","type":"post","link":"https:\/\/old.hemppedia.org\/pl\/cbd-i-celiakia\/","title":{"rendered":"CBD i celiakia"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_57_1 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor: pointer\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\" role=\"button\"><label for=\"item-69f8bab1e0cdc\" ><span class=\"\"><span style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #428bca;color:#428bca\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #428bca;color:#428bca\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input aria-label=\"Toggle\" aria-label=\"item-69f8bab1e0cdc\"  type=\"checkbox\" id=\"item-69f8bab1e0cdc\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/old.hemppedia.org\/pl\/cbd-i-celiakia\/#Czym_jest_celiakia\" title=\"Czym jest celiakia?&nbsp;\">Czym jest celiakia?&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/old.hemppedia.org\/pl\/cbd-i-celiakia\/#Dlaczego_CBD_moze_pomoc_w_chorobie_glutenowej\" title=\"Dlaczego CBD mo\u017ce pom\u00f3c w chorobie glutenowej?&nbsp;\">Dlaczego CBD mo\u017ce pom\u00f3c w chorobie glutenowej?&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/old.hemppedia.org\/pl\/cbd-i-celiakia\/#Co_mowia_badania\" title=\"Co m\u00f3wi\u0105 badania\">Co m\u00f3wi\u0105 badania<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/old.hemppedia.org\/pl\/cbd-i-celiakia\/#Jak_stosowac_CBD_w_przypadku_choroby_glutenowej\" title=\"Jak stosowa\u0107 CBD w przypadku choroby glutenowej?&nbsp;\">Jak stosowa\u0107 CBD w przypadku choroby glutenowej?&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/old.hemppedia.org\/pl\/cbd-i-celiakia\/#Referencje\" title=\"Referencje \">Referencje <\/a><\/li><\/ul><\/nav><\/div>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-top\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;85463&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;top&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;2&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;5&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;4&quot;,&quot;greet&quot;:&quot;Rate post&quot;,&quot;legend&quot;:&quot;5\\\/5 - (2)&quot;,&quot;size&quot;:&quot;20&quot;,&quot;title&quot;:&quot;CBD i celiakia&quot;,&quot;width&quot;:&quot;118&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 118px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 16px;\">\n            5\/5 - (2)    <\/div>\n    <\/div>\n\n<p>CBD jest uznawane na ca\u0142ym \u015bwiecie<sup><a href=\"#footnote_0_85463\" id=\"identifier_0_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Expert Committee on Drug Dependence (2018). CANNABIDIOL (CBD). [online] World Health Organization.\">1<\/a><\/sup> ze wzgl\u0119du na swoje zdrowotne w\u0142a\u015bciwo\u015bci przeciwzapalne<sup><a href=\"#footnote_1_85463\" id=\"identifier_1_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Nagarkatti, Prakash, et al. (2009) &ldquo;Cannabinoids as novel anti-inflammatory drugs.&rdquo; Future medicinal chemistry 1(7).1333-1349.\">2<\/a><\/sup> i zdolno\u015b\u0107 do \u0142agodzenia b\u00f3lu<sup><a href=\"#footnote_2_85463\" id=\"identifier_2_85463\" class=\"footnote-link footnote-identifier-link\" title=\"De Gregorio, D., McLaughlin, R., Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., Aboud, M., Maione, S., Comai, S. and Gobbi, G. (2019). Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. PAIN, 160(1), pp.136-150.\">3<\/a><\/sup> W rezultacie olej CBD mo\u017ce by\u0107 uznane za skuteczne leczenie takich chor\u00f3b jak celiakia, zwan\u0105 potocznie chorob\u0105 glutenow\u0105.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Czym_jest_celiakia\"><\/span><strong>Czym jest celiakia?&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Celiakia jest powszechn\u0105 chorob\u0105 autoimmunologiczn\u0105, kt\u00f3ra dotyka znaczn\u0105 cz\u0119\u015b\u0107 populacji. Reakcja immunologiczna wyst\u0119puje gdy osoby spo\u017cywaj\u0105 gluten w takich produktach spo\u017cywczych jak pszenica, \u017cyto, j\u0119czmie\u0144 czy owies. Spo\u017cywanie glutenu sprawia, \u017ce uk\u0142ad odporno\u015bciowy uwalnia czynniki zapalne, kt\u00f3re powoduj\u0105 przewlek\u0142y stan zapalny b\u0142ony \u015bluzowej jelita cienkiego, skutkuj\u0105cy uszkodzeniem, a nawet zanikiem kosmk\u00f3w jelitowych, odpowiedzialnych za wch\u0142anianie substancji od\u017cywczych dostarczanych do organizmu w postaci jedzenia<sup><a href=\"#footnote_3_85463\" id=\"identifier_3_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Celiac Disease Foundation. (2019). What is Celiac Disease? | Celiac Disease Foundation. [online] Available at: https:\/\/celiac.org\/about-celiac-disease\/what-is-celiac-disease\/.\">4<\/a><\/sup>.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Co to jest CELIAKIA - nietolerancja glutenu\" width=\"980\" height=\"551\" src=\"https:\/\/www.youtube.com\/embed\/GKgVaKdc1LQ?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p>Nieprawid\u0142owe dzia\u0142anie kosmk\u00f3w jelitowych prowadzi do stanu niedo\u017cywienia, a w niekt\u00f3rych ci\u0119\u017ckich przypadkach do utraty g\u0119sto\u015bci ko\u015bci, poronie\u0144, zaburze\u0144 neurologicznych i niep\u0142odno\u015bci. Inne objawy, na kt\u00f3re nale\u017cy zwr\u00f3ci\u0107 uwag\u0119, to biegunka, wzd\u0119cia, nadmiar gaz\u00f3w, zm\u0119czenie, utrata wagi, niedokrwisto\u015b\u0107 z niedoborem \u017celaza, zaparcia, sw\u0119dz\u0105ca wysypka i wrzody w jamie ustnej. U doros\u0142ych celiakia jest nieco skomplikowana, poniewa\u017c mo\u017ce utorowa\u0107 drog\u0119 innym problemom zdrowotnym, takim jak zapalenie staw\u00f3w, osteoporoza, problemy z w\u0105trob\u0105, depresja, napady i opryszczkowate zapalenie sk\u00f3ry<sup><a href=\"#footnote_3_85463\" id=\"identifier_4_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Celiac Disease Foundation. (2019). What is Celiac Disease? | Celiac Disease Foundation. [online] Available at: https:\/\/celiac.org\/about-celiac-disease\/what-is-celiac-disease\/.\">4<\/a><\/sup>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dlaczego_CBD_moze_pomoc_w_chorobie_glutenowej\"><\/span><strong>Dlaczego CBD mo\u017ce pom\u00f3c w chorobie glutenowej?<\/strong>&nbsp;<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CBD jest naturalnym zwi\u0105zkiem otrzymywanym z konopi siewnych (Cannabis Sativa). Zdolno\u015b\u0107 CBD do efektywnego wsp\u00f3\u0142dzia\u0142ania z ludzkim uk\u0142adem endokanabinoidowym jest czynnikiem przyczyniaj\u0105cym si\u0119 do jego skuteczno\u015bci w leczeniu celiakii. System ten sk\u0142ada kannabinoid\u00f3w, takich tak anandamid, enzym\u00f3w, jak r\u00f3wnie\u017c z receptor\u00f3w CB1 i CB2, kt\u00f3re reguluj\u0105 funkcje organizmu takie jak odporno\u015b\u0107, sen, apetyt, b\u00f3l i nastr\u00f3j.<\/p>\n\n\n\n<p>CBD wp\u0142ywa na dzia\u0142anie receptor\u00f3w CB1 i CB2, wzmacniaj\u0105c system odporno\u015bciowy organizmu. Mo\u017ce r\u00f3wnie\u017c pom\u00f3c z\u0142agodzi\u0107 objawy celiakii, takie jak b\u00f3l, stan zapalny, utrata apetytu i podra\u017cnienia, kt\u00f3re wp\u0142ywaj\u0105 na ca\u0142y uk\u0142ad pokarmowy.<\/p>\n\n\n\n<p>Niekt\u00f3rzy pacjenci skar\u017c\u0105 si\u0119 r\u00f3wnie\u017c na nudno\u015bci, kt\u00f3re mog\u0105 prowadzi\u0107 do apetytu i utraty wagi. Olej CBD ma w\u0142a\u015bciwo\u015bci przeciwwymiotne, kt\u00f3re pomog\u0105 z\u0142agodzi\u0107 zar\u00f3wno nudno\u015bci i utrat\u0119 apetytu i zwi\u0119kszy\u0107 metabolizm<sup><a href=\"#footnote_4_85463\" id=\"identifier_5_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Parker, L., Rock, E. and Limebeer, C. (2011). Regulation of nausea and vomiting by cannabinoids. British Journal of Pharmacology, 163(7), pp.1411-1422.\">5<\/a><\/sup>.<\/p>\n\n\n\n<p>W wi\u0119kszo\u015bci przypadk\u00f3w pacjenci decyduj\u0105 si\u0119 na spo\u017cywanie posi\u0142k\u00f3w bezglutenowych, co jest diet\u0105 trudn\u0105 do utrzymania. Jeszcze w 2003 roku badanie dotycz\u0105ce receptor\u00f3w kannabinoidowych u pacjent\u00f3w w celiaki\u0105<sup><a href=\"#footnote_5_85463\" id=\"identifier_6_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Battista, N., Di Sabatino, A., Di Tommaso, M., Biancheri, P., Rapino, C., Giuffrida, P., Papadia, C., Montana, C., Pasini, A., Vanoli, A., Lanzarotto, F., Villanacci, V., Corazza, G. and Maccarrone, M. (2013). Altered Expression of Type-1 and Type-2 Cannabinoid Receptors in Celiac Disease. PLoS ONE, 8(4), p.e62078.\">6<\/a><\/sup> wykaza\u0142o, \u017ce receptory kannabinoidowe w przewodzie pokarmowym by\u0142y bardziej rozpowszechnione u nieleczonych pacjent\u00f3w ni\u017c u tych, kt\u00f3rzy stosowali diet\u0119 bezglutenow\u0105 przez ponad rok. To badanie doprowadzi\u0142o naukowc\u00f3w do przekonania, \u017ce leczenie ukierunkowane na receptory kannabinoidowe, mo\u017ce pom\u00f3c w \u0142agodzeniu objaw\u00f3w celiakii.<\/p>\n\n\n\n<p>Warto r\u00f3wnie\u017c wspomnie\u0107, \u017ce CBD jest inhibitorem enzymu FAAH, znanego r\u00f3wnie\u017c jako hydrolaza amidowo-t\u0142uszczowa<sup><a href=\"#footnote_6_85463\" id=\"identifier_7_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Massi, P., Valenti, M., Vaccani, A., Gasperi, V., Perletti, G., Marras, E., Fezza, F., Maccarrone, M. and Parolaro, D. (2008). 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. Journal of Neurochemistry, 104(4), pp.1091-1100.\">7<\/a><\/sup>. Enzym ten rozk\u0142ada anandamid, kt\u00f3ry ma w\u0142a\u015bciwo\u015bci neuroprotekcyjne. Poprzez hamowanie enzymu FAAH, CBD stymuluje w ten spos\u00f3b dzia\u0142anie przeciwzapalne w jelitach.<br><\/p>\n\n\n\n<p>Wed\u0142ug bada\u0144, celiakia mo\u017ce prowadzi\u0107 r\u00f3wnie\u017c do uszkodzenia nerw\u00f3w<sup><a href=\"#footnote_7_85463\" id=\"identifier_8_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Celiac Disease Foundation. (2019). Neuropathy Linked to Celiac Disease | Celiac Disease Foundation. [online] Available at: https:\/\/celiac.org\/about-the-foundation\/featured-news\/2015\/06\/neuropathy-linked-to-celiac-disease\/.\">8<\/a><\/sup>. CBD mo\u017ce by\u0107 rozwi\u0105zaniem w przypadku neuropatii<sup><a href=\"#footnote_8_85463\" id=\"identifier_9_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Ward, S., McAllister, S., Kawamura, R., Murase, R., Neelakantan, H. and Walker, E. (2014). Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1Areceptors without diminishing nervous system function or chemotherapy efficacy. British Journal of Pharmacology, 171(3), pp.636-645.\">9<\/a><\/sup>, poniewa\u017c ma w\u0142a\u015bciwo\u015bci neuroprotekcyjne<sup><a href=\"#footnote_9_85463\" id=\"identifier_10_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Hampson, A., Grimaldi, M., Axelrod, J. and Wink, D. (1998). Cannabidiol and (-) 9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences, 95(14), pp.8268-8273.\">10<\/a><\/sup> i neurodegeneracyjne<sup><a href=\"#footnote_10_85463\" id=\"identifier_11_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Iuvone, T., Esposito, G., De Filippis, D., Scuderi, C. and Steardo, L. (2009). Cannabidiol: A Promising Drug for Neurodegenerative Disorders?. CNS Neuroscience &amp; Therapeutics, 15(1), pp.65-75.\">11<\/a><\/sup>.&nbsp;<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Co_mowia_badania\"><\/span><strong>Co m\u00f3wi\u0105 badania<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nale\u017cy zauwa\u017cy\u0107, \u017ce ilo\u015b\u0107 bada\u0144 po\u015bwi\u0119conych efektom dzia\u0142ania oleju CBD w zwalczaniu celiakii jest ci\u0105gle ograniczona. Co wi\u0119cej, wi\u0119kszo\u015b\u0107 bada\u0144 nad olejem CBD i celiaki\u0105 zako\u0144czy\u0142a si\u0119 niejednoznacznymi wynikami. Na przyk\u0142ad w 2011 roku w czasopi\u015bmie naukowym PLOS One przedstawiono wyniki bada\u0144 w\u0142oskich naukowc\u00f3w, kt\u00f3rzy byli zdeterminowani, aby oceni\u0107 mo\u017cliwo\u015b\u0107 zmniejszenia stanu zapalnego jelit po zastosowaniu CBD w leczeniu celiakii<sup><a href=\"#footnote_11_85463\" id=\"identifier_12_85463\" class=\"footnote-link footnote-identifier-link\" title=\"De Filippis, D., Esposito, G., Cirillo, C., Cipriano, M., De Winter, B., Scuderi, C., Sarnelli, G., Cuomo, R., Steardo, L., De Man, J. and Iuvone, T. (2011). Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis. PLoS ONE, 6(12), pp.281-9.\">12<\/a><\/sup>. Zgodnie z ich wynikami doszli oni do wniosku, \u017ce CBD reguluje reakcje zapalne w jelicie. W rezultacie zapobiega ona uszkodzeniu jelita, co jest objawem zwi\u0105zanym z celiaki\u0105.<\/p>\n\n\n\n<p>Badania przeprowadzone na Uniwersytecie w Teramo mia\u0142y r\u00f3wnie\u017c na celu analiz\u0119 specyficznych cech uk\u0142adu endokannabinoidowego<sup><a href=\"#footnote_12_85463\" id=\"identifier_13_85463\" class=\"footnote-link footnote-identifier-link\" title=\"semanticscholar.org. (2013). Anecdotal reports of benefit abound Cannabis. [online] Available at: https:\/\/pdfs.semanticscholar.org\/3a67\/a6d84199626f644406e09d01303da91d65a3.pdf.\">13<\/a><\/sup>. Chocia\u017c ich wyniki s\u0105 niejednoznaczne, naukowcy udowodnili istotn\u0105 korelacj\u0119 mi\u0119dzy nieprawid\u0142owym dzia\u0142aniem uk\u0142adu endokannabinoidowego a patogenez\u0105 celiakii.<\/p>\n\n\n\n<p>Niemniej jednak, nale\u017cy przeprowadzi\u0107 wi\u0119cej bada\u0144 w celu zbadania terapeutycznego wp\u0142ywu CBD na \u0142agodzenie objaw\u00f3w celiakii.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Jak_stosowac_CBD_w_przypadku_choroby_glutenowej\"><\/span><strong>Jak stosowa\u0107 CBD w przypadku choroby glutenowej?&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Olej CBD mo\u017ce by\u0107 u\u017cywany na r\u00f3\u017cne sposoby i jest idealnym produktem wzbogacaj\u0105cym diet\u0119 bezglutenow\u0105. Pacjenci najcz\u0119\u015bciej preferuj\u0105 podawanie olejku CBD pod j\u0119zyk i odczekania oko\u0142o minuty przed po\u0142kni\u0119ciem.<\/p>\n\n\n\n<p>Chocia\u017c efekty uboczne olejku CBD s\u0105 rzadkie, warto o nich wiedzie\u0107. W ci\u0105gu kilku pierwszych dni stosowania CBD, mog\u0105 pojawi\u0107 si\u0119 zawroty g\u0142owy, biegunka, wymioty, sucho\u015b\u0107 w ustach, ni\u017csze ci\u015bnienie krwi ni\u017c normalnie czy og\u00f3lne zm\u0119czenie.<\/p>\n\n\n\n<p>Aby znale\u017a\u0107 idealn\u0105 dawk\u0119 CBD dla Twojego konkretnego przypadku, by\u0107 mo\u017ce b\u0119dziesz musia\u0142 troch\u0119 poeksperymentowa\u0107 z dawk\u0105 i obserwowa\u0107 reakcj\u0119 organizmu. \u015awietnym sposobem ustalenia dawki CBD jest metoda step-up, opracowana przez Leinow &amp; Birnbaum w ich ksi\u0105\u017cce &#8220;CBD&#8221;: A patient&#8217;s guide to Medical Cannabis &#8221;<sup><a href=\"#footnote_13_85463\" id=\"identifier_14_85463\" class=\"footnote-link footnote-identifier-link\" title=\"Leinow, L. and Birnbaum, J. (2017). CBD: A Patient&rsquo;s Guide to Medicinal Cannabis. North Atlantic Books.\">14<\/a><\/sup>. Autorzy zalecaj\u0105 rozpoczynanie od ni\u017cszej dawki i powolne zwi\u0119kszanie jej do momentu ust\u0105pienia objaw\u00f3w.<\/p>\n\n\n\n<p>Szczeg\u00f3\u0142owe wyja\u015bnienie metody step-up mo\u017cna znale\u017a\u0107 w naszym przewodniku po <a href=\"https:\/\/hemppedia.org\/pl\/dawkowanie-cbd\/\" target=\"_blank\" rel=\"noreferrer noopener\">dawkowaniu CBD<\/a>.&nbsp;<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Referencje\"><\/span><strong>Referencje<\/strong><br><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ol class=\"footnotes\"><li id=\"footnote_0_85463\" class=\"footnote\">Expert Committee on Drug Dependence (2018). <a href=\"https:\/\/www.who.int\/medicines\/access\/controlled-substances\/CannabidiolCriticalReview.pdf\" target=\"_blank\" rel=\"noopener\"><i>CANNABIDIOL (CBD)<\/i><\/a>. [online] World Health Organization.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_0_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_1_85463\" class=\"footnote\">Nagarkatti, Prakash, et al. (2009) \u201c<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2828614\/\" target=\"_blank\" rel=\"noopener\">Cannabinoids as novel anti-inflammatory drugs.<\/a>\u201d Future medicinal chemistry 1(7).1333-1349.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_85463\" class=\"footnote\">De Gregorio, D., McLaughlin, R., Posa, L., Ochoa-Sanchez, R., Enns, J., Lopez-Canul, M., Aboud, M., Maione, S., Comai, S. and Gobbi, G. (2019). C<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6319597\/\" target=\"_blank\" rel=\"noopener\">annabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.<\/a> PAIN, 160(1), pp.136-150.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_2_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_3_85463\" class=\"footnote\">Celiac Disease Foundation. (2019). What is Celiac Disease? | Celiac Disease Foundation. [online] Available at:<a href=\"https:\/\/celiac.org\/about-celiac-disease\/what-is-celiac-disease\/\" target=\"_blank\" rel=\"noopener\"> https:\/\/celiac.org\/about-celiac-disease\/what-is-celiac-disease\/<\/a>.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_3_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>] [<a href=\"#identifier_4_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_4_85463\" class=\"footnote\">Parker, L., Rock, E. and Limebeer, C. (2011). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3165951\/\" target=\"_blank\" rel=\"noopener\">Regulation of nausea and vomiting by cannabinoid<\/a>s. <em>British Journal of Pharmacology<\/em>, 163(7), pp.1411-1422.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_5_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_5_85463\" class=\"footnote\">Battista, N., Di Sabatino, A., Di Tommaso, M., Biancheri, P., Rapino, C., Giuffrida, P., Papadia, C., Montana, C., Pasini, A., Vanoli, A., Lanzarotto, F., Villanacci, V., Corazza, G. and Maccarrone, M. (2013). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3631143\/\" target=\"_blank\" rel=\"noopener\">Altered Expression of Type-1 and Type-2 Cannabinoid Receptors in Celiac Disease. <\/a>PLoS ONE, 8(4), p.e62078.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_6_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_6_85463\" class=\"footnote\">Massi, P., Valenti, M., Vaccani, A., Gasperi, V., Perletti, G., Marras, E., Fezza, F., Maccarrone, M. and Parolaro, D. (2008).<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1471-4159.2007.05073.x\" target=\"_blank\" rel=\"noopener\"> 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. <\/a>Journal of Neurochemistry, 104(4), pp.1091-1100.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_7_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_7_85463\" class=\"footnote\">Celiac Disease Foundation. (2019). Neuropathy Linked to Celiac Disease | Celiac Disease Foundation. [online] Available at: <a href=\"https:\/\/celiac.org\/about-the-foundation\/featured-news\/2015\/06\/neuropathy-linked-to-celiac-disease\/\" target=\"_blank\" rel=\"noopener\">https:\/\/celiac.org\/about-the-foundation\/featured-news\/2015\/06\/neuropathy-linked-to-celiac-disease\/<\/a>.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_8_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_8_85463\" class=\"footnote\">Ward, S., McAllister, S., Kawamura, R., Murase, R., Neelakantan, H. and Walker, E. (2014). <a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full\/10.1111\/bph.12439\" target=\"_blank\" rel=\"noopener\">Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1Areceptors without diminishing nervous system function or chemotherapy efficacy. <\/a>British Journal of Pharmacology, 171(3), pp.636-645.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_9_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_9_85463\" class=\"footnote\">Hampson, A., Grimaldi, M., Axelrod, J. and Wink, D. (1998). <a href=\"https:\/\/www.pnas.org\/content\/95\/14\/8268.short\" target=\"_blank\" rel=\"noopener\">Cannabidiol and (-) 9-tetrahydrocannabinol are neuroprotective antioxidants.<\/a> Proceedings of the National Academy of Sciences, 95(14), pp.8268-8273. <span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_10_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_10_85463\" class=\"footnote\">Iuvone, T., Esposito, G., De Filippis, D., Scuderi, C. and Steardo, L. (2009).<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/j.1755-5949.2008.00065.x\" target=\"_blank\" rel=\"noopener\"> Cannabidiol: A Promising Drug for Neurodegenerative Disorders?. <\/a>CNS Neuroscience &amp; Therapeutics, 15(1), pp.65-75.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_11_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_11_85463\" class=\"footnote\">De Filippis, D., Esposito, G., Cirillo, C., Cipriano, M., De Winter, B., Scuderi, C., Sarnelli, G., Cuomo, R., Steardo, L., De Man, J. and Iuvone, T. (2011)<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0028159\" target=\"_blank\" rel=\"noopener\">. Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis<\/a>. <em>PLoS ONE<\/em>, 6(12), pp.281-9.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_12_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_12_85463\" class=\"footnote\">semanticscholar.org. (2013). Anecdotal reports of benefit abound Cannabis. [online] Available at: <a href=\"https:\/\/pdfs.semanticscholar.org\/3a67\/a6d84199626f644406e09d01303da91d65a3.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/pdfs.semanticscholar.org\/3a67\/a6d84199626f644406e09d01303da91d65a3.pdf<\/a>.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_13_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_13_85463\" class=\"footnote\">Leinow, L. and Birnbaum, J. (2017). <a href=\"https:\/\/www.goodreads.com\/book\/show\/33946187-cbd\" target=\"_blank\" rel=\"noopener\">CBD: A Patient\u2019s Guide to Medicinal Cannabis<\/a>. North Atlantic Books.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_14_85463\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>CBD jest uznawane na ca\u0142ym \u015bwiecie1 ze wzgl\u0119du na swoje zdrowotne w\u0142a\u015bciwo\u015bci przeciwzapalne2 i zdolno\u015b\u0107 do \u0142agodzenia b\u00f3lu3 W rezultacie olej CBD mo\u017ce by\u0107 uznane za skuteczne leczenie takich chor\u00f3b jak celiakia, zwan\u0105 potocznie chorob\u0105 glutenow\u0105.&nbsp; Czym jest celiakia?&nbsp; Celiakia jest powszechn\u0105 chorob\u0105 autoimmunologiczn\u0105, kt\u00f3ra dotyka znaczn\u0105 cz\u0119\u015b\u0107 populacji. Reakcja immunologiczna wyst\u0119puje gdy osoby spo\u017cywaj\u0105 [&hellip;]<\/p>\n","protected":false},"author":30,"featured_media":82235,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","footnotes":""},"categories":[131],"tags":[],"acf":[],"modified_by":"Hemppedia","_links":{"self":[{"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/posts\/85463"}],"collection":[{"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/comments?post=85463"}],"version-history":[{"count":1,"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/posts\/85463\/revisions"}],"predecessor-version":[{"id":110498,"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/posts\/85463\/revisions\/110498"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/media\/82235"}],"wp:attachment":[{"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/media?parent=85463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/categories?post=85463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/old.hemppedia.org\/pl\/wp-json\/wp\/v2\/tags?post=85463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}