{"id":112250,"date":"2021-11-22T12:44:10","date_gmt":"2021-11-22T11:44:10","guid":{"rendered":"https:\/\/hemppedia.org\/cbd-suppositorier-fullstandig-oversikt\/"},"modified":"2021-11-22T12:53:22","modified_gmt":"2021-11-22T11:53:22","slug":"cbd-suppositorier-fullstandig-oversikt","status":"publish","type":"post","link":"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/","title":{"rendered":"CBD suppositorier &#8211; fullst\u00e4ndig \u00f6versikt"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_57_1 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor: pointer\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\" role=\"button\"><label for=\"item-69f8b8d80673b\" ><span class=\"\"><span style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #428bca;color:#428bca\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #428bca;color:#428bca\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input aria-label=\"Toggle\" aria-label=\"item-69f8b8d80673b\"  type=\"checkbox\" id=\"item-69f8b8d80673b\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Vad_ar_suppositorier\" title=\"Vad \u00e4r suppositorier?\">Vad \u00e4r suppositorier?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Cannabis_suppositorier\" title=\"Cannabis suppositorier\">Cannabis suppositorier<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Anvandning\" title=\"Anv\u00e4ndning\">Anv\u00e4ndning<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Olika_typer_av_suppositorier\" title=\"Olika typer av suppositorier\">Olika typer av suppositorier<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Vem_kan_anvanda_suppositorier\" title=\"Vem kan anv\u00e4nda suppositorier?\">Vem kan anv\u00e4nda suppositorier?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Vad_sager_forskningen\" title=\"Vad s\u00e4ger forskningen?\">Vad s\u00e4ger forskningen?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Framsteg_inom_forskningen\" title=\"Framsteg inom forskningen\">Framsteg inom forskningen<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Slutsats\" title=\"Slutsats\">Slutsats<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/old.hemppedia.org\/sv\/cbd-suppositorier-fullstandig-oversikt\/#Referenser\" title=\"Referenser\">Referenser<\/a><\/li><\/ul><\/nav><\/div>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-top\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;112250&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;top&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;1&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;5&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;4&quot;,&quot;greet&quot;:&quot;Rate post&quot;,&quot;legend&quot;:&quot;5\\\/5 - (1)&quot;,&quot;size&quot;:&quot;20&quot;,&quot;title&quot;:&quot;CBD suppositorier - fullst\\u00e4ndig \\u00f6versikt&quot;,&quot;width&quot;:&quot;118&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 118px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 16px;\">\n            5\/5 - (1)    <\/div>\n    <\/div>\n\n<p>CBD suppositorier \u00e4r piller f\u00f6r att f\u00f6ra in l\u00e4kemedel genom rektum eller vagina. Denna administreringsv\u00e4g f\u00f6r <a href=\"https:\/\/hemppedia.org\/sv\/grundlaggande-om-cbd\/\" target=\"_blank\" rel=\"noopener\">CBD<\/a> anv\u00e4nds vid vissa tillst\u00e5nd och gynnar m\u00e4nniskor vid terapeutisk anv\u00e4ndning. <\/p>\n\n\n\n<p>Suppositorier \u00e4r l\u00e4mpliga f\u00f6r personer som genomg\u00e5r kroniska tillst\u00e5nd. Ger de \u00f6kad biotillg\u00e4nglighet av l\u00e4kemedlet?\r\n<\/p>\n\n\n\n<p>D\u00e4rf\u00f6r syftar den h\u00e4r artikeln till att sammanst\u00e4lla anv\u00e4ndbar information om suppositorier. S\u00e5 att olika sektioner av CBD-anv\u00e4ndare kan dra nytta av att f\u00e5 r\u00e4tt information. Att undvika missbruk av alla l\u00e4kemedel \u00e4r ett individuellt ansvar f\u00f6r personlig och samh\u00e4llelig s\u00e4kerhet.<\/p>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1637581925265\" class=\"rank-math-list-item\">\n<h2 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"Vad_ar_suppositorier\"><\/span>Vad \u00e4r suppositorier?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"rank-math-answer \">\n\n<p>Suppositorier \u00e4r piller som \u00e4r speciellt utformade f\u00f6r att administrera vissa l\u00e4kemedel genom anala eller vaginala \u00f6ppningar. De har i allm\u00e4nhet en konisk eller oval form som inneh\u00e5ller l\u00e4kemedlet.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<p>I en studie fr\u00e5n 2016<sup><a href=\"#footnote_0_112250\" id=\"identifier_0_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Lowry M (2016) Rectal drug administration in adults: how, when, why. Nursing Times; 112:8, 12-14.\">1<\/a><\/sup> om rektal l\u00e4kemedelsadministration beskrivs suppositorier som sm\u00e5 torpedformade pellets som sm\u00e4lter n\u00e4r de f\u00f6rs in i kroppen.<\/p>\n\n\n\n<p>Till exempel:<\/p>\n\n\n\n<ul><li>Glycerin suppositorier som anv\u00e4nds vid behandling av f\u00f6rstoppning,<\/li><li>Paracetamol f\u00f6r att behandla sm\u00e4rta och feber. \r\n<\/li><\/ul>\n\n\n\n<p>I det h\u00e4r l\u00e4get \u00e4r det v\u00e4rt att n\u00e4mna att suppositorier skiljer sig fr\u00e5n lavemang. Enema anv\u00e4nds vanligen som laxermedel f\u00f6r att lindra f\u00f6rstoppning eller f\u00f6r att reng\u00f6ra tarmen inf\u00f6r en medicinsk unders\u00f6kning\/operation. De inneh\u00e5ller v\u00e4tskor och injiceras i analh\u00e5lan.<\/p>\n\n\n\n<p>Ett suppositorium d\u00e4remot \u00e4r ett fast l\u00e4kemedel som f\u00f6rs in i \u00e4ndtarmen och som absorberas helt och h\u00e5llet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cannabis_suppositorier\"><\/span>Cannabis suppositorier<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Cannabis suppositorier inneh\u00e5ller cannabisinblandade oljor i en b\u00e4rarolja. Kakaosm\u00f6r eller gelatin omger medicinen. N\u00e4r de v\u00e4l har f\u00f6rts in i \u00e4ndtarmen sm\u00e4lter de p\u00e5 grund av kroppstemperaturen. Och l\u00e4kemedlet absorberas av kroppen. <\/p>\n\n\n\n<p>Dessutom har rektala administreringsv\u00e4gar f\u00f6r b\u00e5de THC och CBD anv\u00e4nts i \u00e5rtionden, men de \u00e4r inte s\u00e4rskilt popul\u00e4ra. Forts\u00e4tt att l\u00e4sa f\u00f6r att f\u00e5 veta varf\u00f6r?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Anvandning\"><\/span>Anv\u00e4ndning<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul><li>En studie fr\u00e5n 2010<sup><a href=\"#footnote_1_112250\" id=\"identifier_1_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Loyd V. Allen (Professor and Chair) (1997) Suppositories as Drug Delivery Systems, Journal of Pharmaceutical Care in Pain &amp; Symptom Control, 5:2, 17-26, DOI: 10.1300\/J088v05n02_03\">2<\/a><\/sup> rapporterar att suppositorier \u00e4r anv\u00e4ndbara f\u00f6r patienter som inte kan ta l\u00e4kemedel oralt p\u00e5 grund av illam\u00e5ende, kr\u00e4kningar, avancerad sjukdom eller neurologiska brister.\r\n<\/li><\/ul>\n\n\n\n<ul><li>Enligt tillg\u00e4ngliga anekdotiska ber\u00e4ttelser rapporterar patienterna att suppositorier inte ger n\u00e5gon berusning j\u00e4mf\u00f6rt med att r\u00f6ka THC-rik cannabis.<\/li><\/ul>\n\n\n\n<ul><li>Resultaten av en studie fr\u00e5n 2005<sup><a href=\"#footnote_2_112250\" id=\"identifier_2_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Wright K, Rooney N, Feeney M, et al. Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. Gastroenterology. 2005;129(2):437-453. doi:10.1016\/j.gastro.2005.05.026\">3<\/a><\/sup> visar att epitelcellerna i tjocktarmen \u00e4r biokemiskt och funktionellt k\u00e4nsliga f\u00f6r cannabinoider. Dessutom har epiteliala CB1-receptorer en immunmodulerande roll som kan p\u00e5verka slemhinnans immunitet.<\/li><\/ul>\n\n\n\n<ul><li>Personer som lider av kronisk progressiv sjukdom beh\u00f6ver h\u00f6ga niv\u00e5er av THC. Oral konsumtion kan l\u00e4mna patienten psykoaktiv eftersom det mesta av det medicinska inneh\u00e5llet bearbetas i levern. \u00c5 andra sidan ger rektal administrering maximal absorption av THC.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"&quot;Cannabis Suppositories 101&quot;: The Kootenay&#039;s Medicine Tree Talk\" width=\"980\" height=\"551\" src=\"https:\/\/www.youtube.com\/embed\/6sMmlRFC5Mk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div><figcaption>Cannabis Suppositories 101<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Olika_typer_av_suppositorier\"><\/span>Olika typer av suppositorier<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Det finns tre typer av suppositorier. <a href=\"https:\/\/www.webmd.com\/digestive-disorders\/suppositories-how-to-use#1-2\" target=\"_blank\" rel=\"noopener\">De \u00e4r rektala, vaginala och uretrala suppositorier (alprostadil suppositorium)<\/a>. Och var och en av dessa \u00e4r anv\u00e4ndbara f\u00f6r att behandla specifika symtom.<\/p>\n\n\n\n<p>Nedanst\u00e5ende tabell sammanfattar deras anv\u00e4ndbarhet vid behandling av vissa symtom.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>Rektal<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>Vaginal<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>Ureteral<\/strong><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">F\u00f6rstoppning<\/td><td class=\"has-text-align-center\" data-align=\"center\">Bakterie- och svampinfektioner<\/td><td class=\"has-text-align-center\" data-align=\"center\">Erektil dysfunktion<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Hemorrojder<\/td><td class=\"has-text-align-center\" data-align=\"center\">Endometrios sm\u00e4rta<\/td><td class=\"has-text-align-center\" data-align=\"center\">Sexuella funktionsproblem hos m\u00e4n<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Illam\u00e5ende<\/td><td class=\"has-text-align-center\" data-align=\"center\">Torrhet i vaginalen<\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Krampanfall<\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">Schizofreni, bipol\u00e4r sjukdom<\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><td class=\"has-text-align-center\" data-align=\"center\"><\/td><\/tr><\/tbody><\/table><figcaption>Tabell: Typer av suppositorier och deras anv\u00e4ndbarhet<\/figcaption><\/figure>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1637581959857\" class=\"rank-math-list-item\">\n<h2 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"Vem_kan_anvanda_suppositorier\"><\/span>Vem kan anv\u00e4nda suppositorier?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"rank-math-answer \">\n\n<p>B\u00e5de m\u00e4n och kvinnor kan anv\u00e4nda suppositorier. Men baserat p\u00e5 medicinska r\u00e5d som ges av sjukv\u00e5rdspersonal eller experter. Sj\u00e4lvmedicinering av suppositorier kan leda till o\u00f6nskade effekter. Som tumregel g\u00e4ller att \u00f6ppet diskutera med din l\u00e4kare.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vad_sager_forskningen\"><\/span>Vad s\u00e4ger forskningen?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>B\u00e4ckenregionen (k\u00f6nsorganen, urinbl\u00e5san, b\u00e4ckenkolon och \u00e4ndtarmen) rymmer ett ramverk av nerver som kanaliserar till benen och ryggraden. Och kolonv\u00e4vnaderna rymmer CB1- och CB2-receptorer som skulle kunna f\u00f6rmedla THC:s effekter.<\/p>\n\n\n\n<p>D\u00e4rf\u00f6r kan rektala administreringsv\u00e4gar av cannabisolja aktivera cannabinoidreceptorerna, vilket skulle kunna vara till st\u00f6d f\u00f6r behandling av lokala tillst\u00e5nd som hemorrojder eller inflammation. \r\n<\/p>\n\n\n\n<p>L\u00e5t oss kortfattat g\u00e5 igenom n\u00e5gra studier fr\u00e5n 1985- 2019, deras slutsatser om effekterna av den rektala v\u00e4gen f\u00f6r cannabinoidadministrering.\r\n<\/p>\n\n\n\n<ul><li>I studien in-vivo (djurmodell) fr\u00e5n 1985<sup><a href=\"#footnote_3_112250\" id=\"identifier_3_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Perlin E, Smith CG, Nichols AI, et al. Disposition and bioavailability of various formulations of tetrahydrocannabinol in the rhesus monkey. J Pharm Sci. 1985;74(2):171-174. doi:10.1002\/jps.2600740213\">4<\/a><\/sup> drogs slutsatsen att THC inte var biotillg\u00e4ngligt via rektalv\u00e4gen.<\/li><\/ul>\n\n\n\n<ul><li>I likhet med ovanst\u00e5ende slutsats rapporteras i studien fr\u00e5n 1991<sup><a href=\"#footnote_4_112250\" id=\"identifier_4_112250\" class=\"footnote-link footnote-identifier-link\" title=\"ElSohly MA, Stanford DF, Harland EC, et al. Rectal bioavailability of delta-9-tetrahydrocannabinol from the hemisuccinate ester in monkeys. J Pharm Sci. 1991;80(10):942-945. doi:10.1002\/jps.2600801008\">5<\/a><\/sup> att medan oral administrering av \u03949 THC resulterade i oregelbunden och l\u00e5g biotillg\u00e4nglighet, visade den ingen biotillg\u00e4nglighet fr\u00e5n suppositorieformuleringar. Denna studie visade d\u00e4rf\u00f6r att med hj\u00e4lp av en pro-drog som kallas THC-hemisuccinat (THC-HS) var suppositoriet 70-80% biotillg\u00e4ngligt.<\/li><\/ul>\n\n\n\n<ul><li>I en pilotstudie fr\u00e5n 1996<sup><a href=\"#footnote_5_112250\" id=\"identifier_5_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Brenneisen R, Egli A, Elsohly MA, Henn V, Spiess Y. The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. Int J Clin Pharmacol Ther. 1996;34(10):446-452.\">6<\/a><\/sup> var biotillg\u00e4ngligheten vid oral administrering 45-53% j\u00e4mf\u00f6rt med rektal administrering. Detta beror p\u00e5 den h\u00f6gre first-pass-effekten och den l\u00e5ga absorptionen. \u00c4ven n\u00e4r det g\u00e4ller effektiviteten mellan oral och rektal formulering var 25-50%.<\/li><\/ul>\n\n\n\n<ul><li>I en studie fr\u00e5n 1999<sup><a href=\"#footnote_6_112250\" id=\"identifier_6_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Walker L.A., Harland E.C., Best A.M., ElSohly M.A. (1999) &Delta;9-THC Hemisuccinate in Suppository Form as an Alternative to Oral and Smoked THC. In: Nahas G.G., Sutin K.M., Harvey D., Agurell S., Pace N., Cancro R. (eds) Marihuana and Medicine. Humana Press, Totowa, NJ. https:\/\/doi.org\/10.1007\/978-1-59259-710-9_13\">7<\/a><\/sup> betraktas suppositorier som effektiva formuleringar f\u00f6r systematisk tillf\u00f6rsel och uth\u00e5lliga plasmaniv\u00e5er av THC. Detta beror p\u00e5 den oregelbundna absorptionen och den varierande first-pass-effekten av THC vid oral administrering. <\/li><\/ul>\n\n\n\n<ul><li>I motsats till ovanst\u00e5ende observationer anges i en \u00f6versiktsstudie<sup><a href=\"#footnote_7_112250\" id=\"identifier_7_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Gon&ccedil;alves J, Rosado T, Soares S, et al. Cannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determination. Medicines (Basel). 2019;6(1):31. Published 2019 Feb 23.doi:10.3390\/medicines6010031\">8<\/a><\/sup> fr\u00e5n 2019 att rektal administrering \u00e4r en mindre vanlig v\u00e4g f\u00f6r l\u00e4kemedelsadministrering i terapeutiskt syfte och att biotillg\u00e4ngligheten \u00e4r mycket diskrepant beroende p\u00e5 suppositoriets sammans\u00e4ttning.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Framsteg_inom_forskningen\"><\/span>Framsteg inom forskningen<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Inom omr\u00e5det f\u00f6r l\u00e4kemedelstillf\u00f6rsel p\u00e5g\u00e5r st\u00e4ndig forskning och utveckling. Det \u00f6ppnar nya v\u00e4gar f\u00f6r innovation och avsl\u00f6jar dolda m\u00f6jligheter.<\/p>\n\n\n\n<p>En studie fr\u00e5n 2017<sup><a href=\"#footnote_8_112250\" id=\"identifier_8_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Trusha J. Purohit, Sara M. Hanning &amp; Zimei Wu (2018) Advances in rectal drug delivery systems, Pharmaceutical Development and Technology, 23:10, 942-952, DOI: 10.1080\/10837450.2018.1484766\">9<\/a><\/sup> belyser framstegen och de nya tillv\u00e4gag\u00e5ngss\u00e4tten f\u00f6r rektal l\u00e4kemedelsleverans f\u00f6r systemisk cirkulation. <\/p>\n\n\n\n<p>Till exempel:<\/p>\n\n\n\n<p>Nya system f\u00f6r l\u00e4kemedelstillf\u00f6rsel inkluderar suppositorier av ih\u00e5lig typ, termoresponsiva, mucoadhesiva flytande suppositorier och nanopartikul\u00e4ra system.  Dessa nya metoder har visat sig ge b\u00e4ttre kontroll \u00f6ver l\u00e4kemedelstillf\u00f6rseln f\u00f6r lokal och systemisk verkan. \r\n<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Slutsats\"><\/span>Slutsats<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul><li>Cannabis finns \u00f6verallt, fr\u00e5n te till tamponger. Marknaderna \u00f6versv\u00e4mmas av cannabisprodukter. I detta sammanhang \u00e4r det absolut n\u00f6dv\u00e4ndigt med ett individuellt ansvar f\u00f6r att f\u00f6rst\u00e5 f\u00f6rdelarna, inkonsekvenserna och s\u00e4kerhetsaspekterna av rektal l\u00e4kemedelsadministration.<\/li><\/ul>\n\n\n\n<ul><li>Det \u00e4r v\u00e4rt att n\u00e4mna fr\u00e5n en studie fr\u00e5n 2003<sup><a href=\"#footnote_9_112250\" id=\"identifier_9_112250\" class=\"footnote-link footnote-identifier-link\" title=\"Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet. 2003;42(4):327-360. doi:10.2165\/00003088-200342040-00003\">10<\/a><\/sup> att THC:s farmakokinetik varierar beroende p\u00e5 administreringsv\u00e4g. Detta f\u00e5r oss att fr\u00e5ga oss varf\u00f6r de flesta studierna endast fokuserar p\u00e5 biotillg\u00e4nglighet och l\u00e4kemedelstillf\u00f6rsel av THC. Insikten om andra cannabinoider och deras effektivitet i rektalv\u00e4g, s\u00e4rskilt vid terapeutisk anv\u00e4ndning, \u00e4r begr\u00e4nsad.<\/li><\/ul>\n\n\n\n<ul><li>De senaste framstegen med nya system f\u00f6r rektal l\u00e4kemedelstillf\u00f6rsel visar p\u00e5 en lovande potential att leverera direkt till den systemiska cirkulationen. Denna utveckling skulle kunna ge nya m\u00f6jligheter till terapeutisk anv\u00e4ndning av suppositorier med cannabis. <\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Referenser\"><\/span>Referenser<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ol class=\"footnotes\"><li id=\"footnote_0_112250\" class=\"footnote\"> Lowry M (2016) <a href=\"https:\/\/www.nursingtimes.net\/clinical-archive\/neurology\/rectal-drug-administration-in-adults-how-when-why-22-02-2016\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">Rectal drug administration in adults: how, when, why.<\/a> Nursing Times; 112:8, 12-14.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_0_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_1_112250\" class=\"footnote\"> Loyd V. Allen (Professor and Chair) (1997) <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1300\/J088v05n02_03\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">Suppositories as Drug Delivery Systems,<\/a> Journal of Pharmaceutical Care in Pain &amp; Symptom Control, 5:2, 17-26, DOI: <a href=\"https:\/\/doi.org\/10.1300\/J088v05n02_03\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">10.1300\/J088v05n02_03<\/a><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_112250\" class=\"footnote\">Wright K, Rooney N, Feeney M, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16083701\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing. <\/a><em>Gastroenterology<\/em>. 2005;129(2):437-453. doi:10.1016\/j.gastro.2005.05.026<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_2_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_3_112250\" class=\"footnote\">Perlin E, Smith CG, Nichols AI, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2985774\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">Disposition and bioavailability of various formulations of tetrahydrocannabinol in the rhesus monkey<\/a>. <em>J Pharm Sci<\/em>. 1985;74(2):171-174. doi:10.1002\/jps.2600740213<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_3_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_4_112250\" class=\"footnote\">ElSohly MA, Stanford DF, Harland EC, et al. Rectal bioavailability of delta-9-tetrahydrocannabinol from the hemisuccinate ester in monkeys. <em>J Pharm Sci<\/em>. 1991;80(10):942-945. doi:10.1002\/jps.2600801008<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_4_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_5_112250\" class=\"footnote\">Brenneisen R, Egli A, Elsohly MA, Henn V, Spiess Y. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8897084\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.<\/a> <em>Int J Clin Pharmacol Ther<\/em>. 1996;34(10):446-452.<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_5_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_6_112250\" class=\"footnote\"> Walker L.A., Harland E.C., Best A.M., ElSohly M.A. (1999) <a href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-1-59259-710-9_13#citeas\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">\u03949-THC Hemisuccinate in Suppository Form as an Alternative to Oral and Smoked THC.<\/a> In: Nahas G.G., Sutin K.M., Harvey D., Agurell S., Pace N., Cancro R. (eds) Marihuana and Medicine. Humana Press, Totowa, NJ. https:\/\/doi.org\/10.1007\/978-1-59259-710-9_13<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_6_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_7_112250\" class=\"footnote\">Gon\u00e7alves J, Rosado T, Soares S, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6473697\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">Cannabis and Its Secondary Metabolites: Their Use as Therapeutic Drugs, Toxicological Aspects, and Analytical Determination. <\/a><em>Medicines (Basel)<\/em>. 2019;6(1):31. Published 2019 Feb 23.doi:10.3390\/medicines6010031<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_7_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_8_112250\" class=\"footnote\">Trusha J. Purohit, Sara M. Hanning &amp; Zimei Wu (2018) <a href=\"https:\/\/www.tandfonline.com\/doi\/citedby\/10.1080\/10837450.2018.1484766?scroll=top&amp;needAccess=true\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">Advances in rectal drug delivery systems, Pharmaceutical Development and Technology, <\/a>23:10, 942-952, DOI: 10.1080\/10837450.2018.1484766<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_8_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_9_112250\" class=\"footnote\">Grotenhermen F. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12648025\/\" target=\"_blank\" aria-label=\" (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">Pharmacokinetics and pharmacodynamics of cannabinoids<\/a>. <em>Clin Pharmacokinet<\/em>. 2003;42(4):327-360. doi:10.2165\/00003088-200342040-00003<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_9_112250\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>CBD suppositorier \u00e4r piller f\u00f6r att f\u00f6ra in l\u00e4kemedel genom rektum eller vagina. Denna administreringsv\u00e4g f\u00f6r CBD anv\u00e4nds vid vissa tillst\u00e5nd och gynnar m\u00e4nniskor vid terapeutisk anv\u00e4ndning. <\/p>\n","protected":false},"author":30,"featured_media":101156,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","footnotes":""},"categories":[268],"tags":[],"acf":[],"modified_by":"Hemppedia","_links":{"self":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts\/112250"}],"collection":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/comments?post=112250"}],"version-history":[{"count":3,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts\/112250\/revisions"}],"predecessor-version":[{"id":112256,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts\/112250\/revisions\/112256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/media\/101156"}],"wp:attachment":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/media?parent=112250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/categories?post=112250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/tags?post=112250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}