{"id":112257,"date":"2021-11-22T13:40:31","date_gmt":"2021-11-22T12:40:31","guid":{"rendered":"https:\/\/hemppedia.org\/thc-vs-thca\/"},"modified":"2021-11-22T13:43:17","modified_gmt":"2021-11-22T12:43:17","slug":"thc-vs-thca","status":"publish","type":"post","link":"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/","title":{"rendered":"THC vs THCa"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_57_1 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title ez-toc-toggle\" style=\"cursor: pointer\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\" role=\"button\"><label for=\"item-69f8df6c5524a\" ><span class=\"\"><span style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #428bca;color:#428bca\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #428bca;color:#428bca\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input aria-label=\"Toggle\" aria-label=\"item-69f8df6c5524a\"  type=\"checkbox\" id=\"item-69f8df6c5524a\"><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Introduktion\" title=\"Introduktion\">Introduktion<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#THC_och_THCA_%E2%80%93_en_snabb_oversikt\" title=\"THC och THCA &#8211; en snabb \u00f6versikt\">THC och THCA &#8211; en snabb \u00f6versikt<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Bakgrund_till_THC\" title=\"Bakgrund till THC\">Bakgrund till THC<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Var_finns_THC\" title=\"Var finns THC?\">Var finns THC?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#THC_s_roll_i_det_endocannabinoida_systemet\" title=\"THC:s roll i det endocannabinoida systemet\">THC:s roll i det endocannabinoida systemet<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Medicinska_fordelar_med_THC\" title=\"Medicinska f\u00f6rdelar med THC\">Medicinska f\u00f6rdelar med THC<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#THC_Overanvandning_eller_effekter\" title=\"THC: \u00d6veranv\u00e4ndning eller effekter\">THC: \u00d6veranv\u00e4ndning eller effekter<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Vad_ar_THCa\" title=\"Vad \u00e4r THCa\">Vad \u00e4r THCa<\/a><ul class='ez-toc-list-level-3'><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Var_finns_THCa\" title=\"Var finns THCa?\">Var finns THCa?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Medicinska_fordelar_med_THCa\" title=\"Medicinska f\u00f6rdelar med THCa\">Medicinska f\u00f6rdelar med THCa<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Forskning_om_THCa-A\" title=\"Forskning om THCa-A\">Forskning om THCa-A<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Slutsats\" title=\"Slutsats\">Slutsats<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/old.hemppedia.org\/sv\/thc-vs-thca\/#Kallor\" title=\"K\u00e4llor\">K\u00e4llor<\/a><\/li><\/ul><\/nav><\/div>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-top\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;112257&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;top&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;1&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;5&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;4&quot;,&quot;greet&quot;:&quot;Rate post&quot;,&quot;legend&quot;:&quot;5\\\/5 - (1)&quot;,&quot;size&quot;:&quot;20&quot;,&quot;title&quot;:&quot;THC vs THCa&quot;,&quot;width&quot;:&quot;118&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n    \n<div class=\"kksr-stars-active\" style=\"width: 118px;\">\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" style=\"padding-right: 4px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 20px; height: 20px;\"><\/div>\n        <\/div>\n    <\/div>\n<\/div>\n                \n\n<div class=\"kksr-legend\" style=\"font-size: 16px;\">\n            5\/5 - (1)    <\/div>\n    <\/div>\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Introduktion\"><\/span>Introduktion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>THC och THCa h\u00e4rstammar fr\u00e5n samma grundsubstans CBG, men har olika egenskaper.<\/p>\n\n\n\n<p>THC eller Tetrahydrocannabinol \u00e4r en av de naturligt f\u00f6rekommande cannabinoiderna som renas fr\u00e5n cannabisplantor. Tetrahydrocannabinolsyra (THCa) \u00e4r THC:s sura prekursor.<\/p>\n\n\n\n<p>Sedan uppfinnandet av THC 1964 har det st\u00e5tt i centrum p\u00e5 grund av sitt terapeutiska v\u00e4rde och sina psykoaktiva egenskaper. Vissa delar av missbruket av substansen har gjort den otillg\u00e4nglig f\u00f6r dem som skulle kunna dra nytta av dess medicinska egenskaper. \r\n<\/p>\n\n\n\n<p>B\u00e4ttre kunskap och \u00f6kad medvetenhet skulle d\u00e4rf\u00f6r kunna bidra till att strukturera den v\u00e4xande industrin.\r\n<\/p>\n\n\n\n<p>Syftet med denna artikel \u00e4r att presentera de viktigaste skillnaderna mellan THC och THCa p\u00e5 basis av vetenskapliga bevis och samtidigt f\u00f6rst\u00e5 f\u00f6rdelarna med var och en av dessa \u00e4mnen.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"THC_och_THCA_%E2%80%93_en_snabb_oversikt\"><\/span>THC och THCA &#8211; en snabb \u00f6versikt<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>\u00c4mne<\/strong><\/td><td><strong>THC<\/strong><\/td><td><strong>THCa<\/strong><\/td><\/tr><tr><td><strong>Cannabinoid<\/strong><\/td><td>Naturligt f\u00f6rekommande<\/td><td>Naturligt f\u00f6rekommande<\/td><\/tr><tr><td><strong>Biosyntes<\/strong><\/td><td>THCa dekarboxylas till THC<\/td><td>THCa \u00e4r en f\u00f6reg\u00e5ngare till THC. Det \u00e4r den syra som kontrollerar psykoaktiviteten hos cannabis sativa.<\/td><\/tr><tr><td><strong>Psykoaktivitet<\/strong><\/td><td>Psykoaktiv<\/td><td>Icke-psykoaktiv<\/td><\/tr><tr><td><strong>F\u00f6rdelar<\/strong><\/td><td>Terapeutiska anv\u00e4ndningsomr\u00e5den och rekreation<\/td><td>Terapeutiska anv\u00e4ndningsomr\u00e5den<\/td><\/tr><tr><td><strong>Tillg\u00e4nglighet<\/strong><\/td><td>THCa m\u00e5ste dekarberas f\u00f6r att man ska f\u00e5 fram THC<\/td><td>Kan finnas i nysk\u00f6rdade v\u00e4xter<\/td><\/tr><tr><td><strong>Molekyl\u00e4r struktur<\/strong><\/td><td><a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/delta9-Tetrahydrocannabinol\" target=\"_blank\" rel=\"noopener\">C21H30O2<\/a><\/td><td><a href=\"http:\/\/www.chemspider.com\/Chemical-Structure.88974.html\" target=\"_blank\" rel=\"noopener\">C<sub>22<\/sub>H<sub>30<\/sub>O<sub>4<\/sub><\/a><sub>&nbsp;<\/sub><\/td><\/tr><tr><td><strong>Interaktion med ECS<\/strong><\/td><td>Uppvisar h\u00f6g affinitet och fysiologisk aktivitet<\/td><td>Har d\u00e5lig potens vid CB-receptorer<\/td><\/tr><\/tbody><\/table><figcaption>THC och THCa<\/figcaption><\/figure>\n\n\n\n<p>Tabellen ovan ger en snabb \u00f6verblick \u00f6ver skillnaden mellan THC och THCa. Det finns mer att veta fr\u00e5n vetenskapliga referenser.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bakgrund_till_THC\"><\/span>Bakgrund till THC<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>L\u00e5t oss b\u00f6rja med n\u00e5gra referenser fr\u00e5n litteraturen, en studie fr\u00e5n 2006<sup><a href=\"#footnote_0_112257\" id=\"identifier_0_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Pertwee RG. Cannabinoid pharmacology: the first 66 years. Br J Pharmacol. 2006;147 Suppl 1(Suppl 1): S163-S171. doi:10.1038\/sj.bjp.0706406\">1<\/a><\/sup> ger en h\u00e4nvisning till att THC f\u00f6rst extraherades av Wollner, Matchett, Levine och Loewe \u00e5r 1942 som en blandning av -\u03948 och \u0394-9 THC. Senare, \u00e5r 1964, h\u00e4rleddes och syntetiserades dess isolerade form \u03949THC fr\u00e5n cannabis i Raphael Mechoulams laboratorium. Och deras kemiska strukturer avkodades ocks\u00e5. \r\n<\/p>\n\n\n\n<p>Tetrahydrocannabinol eller \u03949 THC \u00e4r den prim\u00e4ra psykoaktiva komponenten i cannabisplantan som \u00e4r k\u00e4nd f\u00f6r sina neurologiska och psykologiska effekter. <\/p>\n\n\n\n<p>Redan innan vi b\u00f6rjar diskutera THC:s morfologi kan en kort \u00f6versikt \u00f6ver dess kemotyper bidra till att f\u00f6renkla v\u00e5r f\u00f6rst\u00e5else av THC. <\/p>\n\n\n\n<ul><li>Enligt en studie fr\u00e5n 2011<sup><a href=\"#footnote_1_112257\" id=\"identifier_1_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344-1364. doi:10.1111\/j.1476-5381.2011.01238.x\">2<\/a><\/sup> \u00e4r THC den vanligaste fytocannabinoiden som produceras i cannabisdrogens kemotyper.<\/li><\/ul>\n\n\n\n<ul><li>\u00c4ven om det har funnits olika tillv\u00e4gag\u00e5ngss\u00e4tt f\u00f6r att klassificera kemotyperna av cannabis, rapporterar analysen fr\u00e5n en studie fr\u00e5n 2016<sup><a href=\"#footnote_2_112257\" id=\"identifier_2_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Brian F. Thomas, Mahmoud A. ElSohly, Chapter 1 &ndash; The Botany of Cannabis sativa L., Editor(s): Brian F. Thomas, Mahmoud A. ElSohly, The Analytical Chemistry of Cannabis, Elsevier,2016, Pages 1-26, ISBN 9780128046463\">3<\/a><\/sup> att cannabis f\u00f6rst 1971 karakt\u00e4riserades i tv\u00e5 fenotyper. Den tredje kategorin identifierades 1973.<\/li><\/ul>\n\n\n\n<ol><li>THC:CBD-f\u00f6rh\u00e5llandet &gt; 1 var det en drogtyp<\/li><li>THC:CBD <\/li><li>THC: CBD n\u00e4ra 1 &#8211; Intermedi\u00e4r typ<\/li><\/ol>\n\n\n\n<ul><li>F\u00f6ljt av studien fr\u00e5n 2018<sup><a href=\"#footnote_3_112257\" id=\"identifier_3_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, Lorenzo Corsi, &ldquo;Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer&rdquo;, BioMed Research International, vol. 2018, Article ID 1691428, 15 pages, 2018. https:\/\/doi.org\/10.1155\/2018\/1691428\">4<\/a><\/sup> ger ytterligare en insikt. Nedanst\u00e5ende tabell ger en sammanfattning av densamma.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Kemotyp<\/strong><\/td><td><strong>Egenskaper<\/strong><\/td><td><strong>Anv\u00e4ndning<\/strong><\/td><\/tr><tr><td>I<\/td><td>V\u00e4xter av drogtyp med en dominans av cannabinoider av \u03949-THC-typ.<\/td><td>-Medicinska \u00e4ndam\u00e5l eller rekreations\u00e4ndam\u00e5l, -Mest unders\u00f6kta<\/td><\/tr><tr><td>II<\/td><td>V\u00e4xter med intermedi\u00e4ra egenskaper mellan v\u00e4xter av l\u00e4kemedelstyp och v\u00e4xter av fibertyp.<\/td><td>-Textil- och livsmedels\u00e4ndam\u00e5l<\/td><\/tr><tr><td>&nbsp; &nbsp; III &amp; IV<\/td><td>V\u00e4xter av fibertyp som inneh\u00e5ller h\u00f6ga halter av icke-psykoaktiva cannabinoider och mycket l\u00e5ga halter av psykoaktiva cannabinoider.<\/td><td>-Textil- eller livsmedels\u00e4ndam\u00e5l- Inneh\u00e5ller cannabinoidsyror, cannabidiolsyra (CBDA), cannabigerolsyra (CBGa), f\u00f6ljt av deras dekarboxylerade former: cannabidiol (CBD) och cannabigerol (CBG).<\/td><\/tr><tr><td>V<\/td><td>V\u00e4xter av fibertyp som n\u00e4stan inte inneh\u00e5ller n\u00e5gra cannabinoider<\/td><td>-Europeiska l\u00e4nder har godk\u00e4nt kommersiell anv\u00e4ndning. -Det kommersiella v\u00e4rdet av hampa och en laglig gr\u00e4ns p\u00e5 0,2-0,3% THC till\u00e4mpas vanligtvis.<\/td><\/tr><\/tbody><\/table><figcaption>Cannabis: Kemotyper, egenskaper och anv\u00e4ndningsomr\u00e5den<\/figcaption><\/figure>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1637584885681\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"Var_finns_THC\"><\/span>Var finns THC?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"rank-math-answer \">\n\n<p>THC finns i trikomerna p\u00e5 cannabisplantan. Dessa \u00e4r h\u00e5rliknande strukturer p\u00e5 ytan, vars huvud liknar en kristall och som \u00e4r kopplade till en stj\u00e4lk. Trikomernas grundl\u00e4ggande funktion \u00e4r att ge v\u00e4xten en sj\u00e4lvf\u00f6rsvarsmekanism. <\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<p>En studie fr\u00e5n 2012<sup><a href=\"#footnote_4_112257\" id=\"identifier_4_112257\" class=\"footnote-link footnote-identifier-link\" title=\"War AR, Paulraj MG, Ahmad T, et al. Mechanisms of plant defense against insect herbivores. Plant Signal Behav. 2012;7(10):1306-1320. doi:10.4161\/psb.21663\">5<\/a><\/sup> pekar ut som &#8220;direkta f\u00f6rsvar&#8221; som \u00e4r karakteristiska f\u00f6r v\u00e4xtens biologi som fungerar som mekaniskt skydd p\u00e5 ytan. <\/p>\n\n\n\n<p>Till exempel h\u00e5rstr\u00e5n, trikomer, taggar, piggar eller tjocka blad. \u00c4nnu fler terpenoider, alkaloider, fenoler som antingen d\u00f6dar eller f\u00f6rdr\u00f6jer insekter eller djur.<\/p>\n\n\n\n<p>Dessutom klarg\u00f6r slutsatser fr\u00e5n studien fr\u00e5n 2012<sup><a href=\"#footnote_5_112257\" id=\"identifier_5_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Happyana, Nizar &amp; Agnolet, Sara &amp; Muntendam, Remco &amp; Dam, Annie &amp; Schneider, Bernd &amp; Kayser, Oliver. (2012). Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR. Phytochemistry. 87. 10.1016\/j.phytochem.2012.11.001\">6<\/a><\/sup> att dessa trikomer inneh\u00e5ller rikligt med cannabinoider. De stora trikomerna med huvudformade stj\u00e4lkar inneh\u00e5ller tetrahydrocannabinolsyra (THCA), cannabidiolsyra (CBDA), cannabigerolsyra (CBGA) inklusive deras dekarboxylerade derivat Tetrahydrocannabinol THC, cannabidiol CBD och cannabigerol CBG.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"THC_s_roll_i_det_endocannabinoida_systemet\"><\/span>THC:s roll i det endocannabinoida systemet<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Endocannabinoiderna och deras receptorer finns i hela kroppen och \u00e4r inblandade i alla organs komplexa \u00e5tg\u00e4rder. Bland annat immunf\u00f6rsvaret och nervsystemet.<\/p>\n\n\n\n<p>\u00c4n mer, studien fr\u00e5n 2013<sup><a href=\"#footnote_6_112257\" id=\"identifier_6_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Alger BE. Getting high on the endocannabinoid system. Cerebrum. 2013;2013:14. Published 2013 Nov 1\">7<\/a><\/sup> h\u00e4vdar att endocannabinoiderna \u00e4r de viktigaste fysiologiska aktivatorerna av CB1 och CB2, men de \u00e4r \u00e4nd\u00e5 inte vanliga neurotransmittorer.<\/p>\n\n\n\n<p>Fr\u00e5n studien fr\u00e5n 2017<sup><a href=\"#footnote_7_112257\" id=\"identifier_7_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Kendall DA, Yudowski GA. Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease. Front Cell Neurosci. 2017;10:294. Published 2017 Jan 4. doi:10.3389\/fncel.2016.00294\">8<\/a><\/sup> kan vi f\u00f6rst\u00e5 att CB1-receptorn \u00e4r den dominerande formen med rikliga G -proteinkopplade receptorer som finns i hj\u00e4rnan, centrala nervsystemet, levern och njurarna. <\/p>\n\n\n\n<p>\u00c4nnu viktigare \u00e4r att det \u00e4r denna CB1-receptor som binder den huvudsakliga psykoaktiva ingrediensen i marijuana som \u00e4r THC och efterliknar dess effekter. <\/p>\n\n\n\n<p>CB2-receptorerna d\u00e4remot arbetar mer oberoende och finns i immunf\u00f6rsvarets celler och v\u00e4vnader. De uppvisar ett mer definierat m\u00f6nster i hj\u00e4rnan. <\/p>\n\n\n\n<p>I ett n\u00f6tskal, enligt studien fr\u00e5n 2013,<sup><a href=\"#footnote_6_112257\" id=\"identifier_8_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Alger BE. Getting high on the endocannabinoid system. Cerebrum. 2013;2013:14. Published 2013 Nov 1\">7<\/a><\/sup> verkar THC p\u00e5 hj\u00e4rnan genom att ta sig in i det neuronala signalsystemet (receptorerna) genom att efterlikna det och kapa det. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Medicinska_fordelar_med_THC\"><\/span>Medicinska f\u00f6rdelar med THC<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul><li>En studie fr\u00e5n 2011<sup><a href=\"#footnote_8_112257\" id=\"identifier_9_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011;163(7):1344-1364. doi:10.1111\/j.1476-5381.2011.01238.x\">9<\/a><\/sup> rapporterar om THC:s sm\u00e4rtstillande, muskelavslappnande och krampl\u00f6sande egenskaper. Dessutom \u00e4r det en bronkdilaterande, neuroprotektiv antioxidant och har 20 g\u00e5nger mer antiinflammatorisk effekt \u00e4n aspirin.<\/li><\/ul>\n\n\n\n<ul><li>I en studie fr\u00e5n 2019<sup><a href=\"#footnote_9_112257\" id=\"identifier_10_112257\" class=\"footnote-link footnote-identifier-link\" title=\"University of New Mexico. THC found more important for therapeutic effects in cannabis than originally thought: Researchers measure product characteristics and associated effects with mobile app.&rdquo; ScienceDaily. ScienceDaily, 26 February 2019\">10<\/a><\/sup> har det rapporterats att THC har genererat m\u00e4tbara f\u00f6rb\u00e4ttringar i symtomlindring. Liksom denna studie betonar att cannabis med THC skulle kunna bli mer allm\u00e4nt tillg\u00e4ngligt f\u00f6r farmaceutisk anv\u00e4ndning.\r\n<\/li><\/ul>\n\n\n\n<ul><li>I en \u00f6versiktsstudie fr\u00e5n 2014<sup><a href=\"#footnote_10_112257\" id=\"identifier_11_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Webb CW, Webb SM. Therapeutic benefits of cannabis: a patient survey. Hawaii J Med Public Health. 2014;73(4):109-111\">11<\/a><\/sup> som genomf\u00f6rdes bland 100 patienter som anv\u00e4nde cannabis under ett \u00e5r rapporterade om n\u00e5gra av de terapeutiska f\u00f6rdelarna. De \u00e4r lindring av stress, \u00e5ngest, s\u00f6mnl\u00f6shet, f\u00f6rb\u00e4ttrad aptit, lindring av depression och avbrott fr\u00e5n mediciner mot sm\u00e4rta.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"THC_Overanvandning_eller_effekter\"><\/span>THC: \u00d6veranv\u00e4ndning eller effekter<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>F\u00f6rutom den v\u00e4xande kunskapen om omfattningen av terapeutiska till\u00e4mpningar av medicinsk marijuana \u00e4r det alltid bra att lika mycket f\u00f6rst\u00e5 konsekvenserna av \u00f6veranv\u00e4ndning eller missbruk. <\/p>\n\n\n\n<p>I en studie fr\u00e5n 2014<sup><a href=\"#footnote_11_112257\" id=\"identifier_12_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Volkow ND, Baler RD, Compton WM, Weiss SR. Adverse health effects of marijuana use N Engl J Med. 2014;370(23):2219-2227. doi:10.1056\/NEJMra1402309\">12<\/a><\/sup> p\u00e5pekas risker f\u00f6r beroende. S\u00e4rskilt marijuanaanv\u00e4ndning bland ungdomar \u00e4r problematisk. F\u00f6rutom detta \u00e4r f\u00f6rs\u00e4mrad neuronal koppling i specifika hj\u00e4rnregioner, \u00f6kad risk f\u00f6r \u00e5ngest och depression, psykoser f\u00f6r personer med f\u00f6rhistoria \u00e4r n\u00e5gra av de risker som tillskrivs marijuanaanv\u00e4ndning.<\/p>\n\n\n\n<p>\u00c4nnu viktigare \u00e4r att \u00f6veranv\u00e4ndning av marijuana ger negativa effekter n\u00e4r det g\u00e4ller riskerna f\u00f6r trafikolyckor. <\/p>\n\n\n\n<p>I en studie fr\u00e5n 2020<sup><a href=\"#footnote_12_112257\" id=\"identifier_13_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Yuan Wei Peng, Ediriweera Desapriya, Herbert Chan, Jeffrey R Brubacher,&ldquo;Residual blood THC levels in frequent cannabis users after over four hours of abstinence: A systematic review.&rdquo; Drug and Alcohol Dependence, Volume 216, 2020,108177, ISSN 0376-8716\">13<\/a><\/sup> rapporteras att THC orsakar psykomotorisk neds\u00e4ttning och \u00f6kar risken f\u00f6r kollisioner med fordon. Regelbundna cannabisanv\u00e4ndare tenderar att uppvisa en ih\u00e5llande \u00f6kning av THC \u00e4ven efter en period av avh\u00e5llsamhet. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Vad_ar_THCa\"><\/span>Vad \u00e4r THCa<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Tetrahydrocannabinolsyra, en icke-intoxikerande f\u00f6rening, finns naturligt i levande eller nysk\u00f6rdade cannabisplantor. Dekarboxyleringsprocessen \u00e4ger rum n\u00e4r v\u00e4xten torkar och uts\u00e4tts f\u00f6r v\u00e4rme. D\u00e4refter omvandlas THCa till THC. \r\n<\/p>\n\n\n\n<p>I det h\u00e4r l\u00e4get \u00e4r det viktigt att f\u00f6rst\u00e5 att alla de viktigaste cannabinoiderna <a href=\"https:\/\/www.endotext.com\/wp-content\/uploads\/2019\/07\/THCV-Research.pdf\" target=\"_blank\" rel=\"noopener\">b\u00f6rjar sitt liv som CBGA<\/a> (cannabigerolsyra). D\u00e4rf\u00f6r kallas den ocks\u00e5 f\u00f6r modern till alla cannabinoider. Mognad, exponering f\u00f6r v\u00e4rme, ljus eller andra drivkrafter (inklusive f\u00f6rbr\u00e4nning eller f\u00f6r\u00e5ngning) initierar termisk dekarboxylering. \r\n<\/p>\n\n\n\n<p>En studie fr\u00e5n 2009<sup><a href=\"#footnote_13_112257\" id=\"identifier_14_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Taura F. Studies on tetrahydrocannabinolic acid synthase that produces the acidic precursor of tetrahydrocannabinol, the pharmacologically active cannabinoid in marijuana. Drug Discov Ther. 2009;3(3):83-87\">14<\/a><\/sup> illustrerar att THCA \u00e4r den sura prekursorn till THC genom icke-enzymatisk dekarboxylering. Dessutom biosyntetiseras THCa av THCa-syntas fr\u00e5n den biosyntetiska reaktionen av CBGa (cannabigerolsyra). \r\n<\/p>\n\n\n\n<p>Som du kan se i bilden nedan \u00e4r utvecklingen av dessa cannabinoider representerade i deras kemiska struktur, Den h\u00f6gra sidan (B) i bilden visar omvandlingen av CBGa till CBN till CBG. Den v\u00e4nstra sidan (A) visar omvandlingen av THCa och CBDa till THC respektive CBD. I varje steg elimineras den sura karboxylgruppen. \r\n<\/p>\n\n\n\n<p>Dessutom b\u00f6rjar de &#8220;sex stora&#8221; cannabinoiderna THC, CBD, CBG, CBN, CBC och THCV sitt liv i sura former. CBGa omvandlas d\u00e4rf\u00f6r till THCa, CBDa och CBCa.<\/p>\n\n\n\n<figure class=\"wp-block-gallery columns-1 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\"><ul class=\"blocks-gallery-grid\"><li class=\"blocks-gallery-item\"><figure><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"391\" src=\"https:\/\/hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids-1024x391.jpg\" alt=\"\" data-id=\"101166\" data-full-url=\"https:\/\/hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids.jpg\" data-link=\"https:\/\/hemppedia.org\/?attachment_id=101166\" class=\"wp-image-101177\" srcset=\"https:\/\/old.hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids-1024x391.jpg 1024w, https:\/\/old.hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids-300x115.jpg 300w, https:\/\/old.hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids-768x293.jpg 768w, https:\/\/old.hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids-60x23.jpg 60w, https:\/\/old.hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids-150x57.jpg 150w, https:\/\/old.hemppedia.org\/wp-content\/uploads\/2020\/11\/THCA-to-THC-and-other-cannabinoids.jpg 1086w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" title=\"\"><\/figure><\/li><\/ul><figcaption class=\"blocks-gallery-caption\">Bild fr\u00e5n en studie fr\u00e5n 2019.<sup><a href=\"#footnote_14_112257\" id=\"identifier_15_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Lewis-Bakker, Melissa &amp; Yang, Yi &amp; Vyawahare, Rupali &amp; Kotra, Lakshmi. (2019). Extractions of Medical Cannabis Cultivars and the Role of Decarboxylation in Optimal Receptor Responses. Cannabis and Cannabinoid Research. 4. 10.1089\/can.2018.0067\">15<\/a><\/sup><\/figcaption><\/figure>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-question-1637584948431\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \"><span class=\"ez-toc-section\" id=\"Var_finns_THCa\"><\/span>Var finns THCa?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"rank-math-answer \">\n\n<p>THCA finns l\u00e4tt tillg\u00e4ngligt i f\u00e4rskt v\u00e4xtmaterial, vars blad kan tuggas eller pressas. Detta ger dock inga psykoaktiva effekter.  <\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Medicinska_fordelar_med_THCa\"><\/span>Medicinska f\u00f6rdelar med THCa<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Forskningen om cannabinoider v\u00e4xer som aldrig f\u00f6rr p\u00e5 grund av dess lovande egenskaper i terapeutiska till\u00e4mpningar.<\/p>\n\n\n\n<p>\u00c4ven om flera studier har b\u00f6rjat fokusera sin uppm\u00e4rksamhet p\u00e5 THCa:s medicinska f\u00f6rdelar \u00e4r den tillg\u00e4ngliga forskningen <a href=\"https:\/\/www.leafly.com\/news\/cannabis-101\/what-is-thca-and-what-are-the-benefits-of-this-cannabinoid\" target=\"_blank\" rel=\"noopener\">anekdotiska bevis och patientjournaler<\/a>. N\u00e5gra av de potentiella f\u00f6rdelarna kan vara:<\/p>\n\n\n\n<ul><li>Antiinflammatorisk<\/li><li>Neuroprotektiva egenskaper<\/li><li>Antiemetisk<\/li><li>Antiproliferativ<\/li><li>S\u00f6mnl\u00f6shet<\/li><li>Sm\u00e4rtlindring<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Forskning_om_THCa-A\"><\/span>Forskning om THCa-A<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul><li>I en studie fr\u00e5n 2016<sup><a href=\"#footnote_15_112257\" id=\"identifier_16_112257\" class=\"footnote-link footnote-identifier-link\" title=\"Moreno-Sanz, Guillermo.&nbsp; Can You Pass the Acid Test? Critical Review and Novel Therapeutic Perspectives of &Delta; 9 -Tetrahydrocannabinolic Acid A. Cannabis and Cannabinoid Research. 1. 10.1089\/can.2016.0008\">16<\/a><\/sup> presenteras n\u00e5gra av de terapeutiska potentiella f\u00f6rdelarna med st\u00f6d av cellbaserade experiment p\u00e5 THCa-A.\r\n\r\nDe skulle kunna ut\u00f6va:<\/li><\/ul>\n\n\n\n<p> (i) immunmodulerande, (ii) antiinflammatoriska, (iii) neuroprotektiva och (iv) antineoplastiska effekter.<\/p>\n\n\n\n<p>Studien klarg\u00f6r ocks\u00e5 de oklarheter som fanns om THCa-A:<\/p>\n\n\n\n<p>1965 &#8211; F\u00f6rsta identifiering av THCa &#8211; Prof. Friedhelm Korte<\/p>\n\n\n\n<p>1969 &#8211; Raphael Mecholam rapporterade att det fanns ytterligare en syra &#8211; en isomer till THCa, och gav den f\u00f6rstn\u00e4mnda THCa-A och den sistn\u00e4mnda THCa-B namnet.\r\n<\/p>\n\n\n\n<ul><li>Dessutom rapporterar en studie fr\u00e5n 2017<sup><a href=\"#footnote_16_112257\" id=\"identifier_17_112257\" class=\"footnote-link footnote-identifier-link\" title=\"McPartland JM, MacDonald C, Young M, Grant PS, Furkert DP, Glass M. Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two. Cannabis Cannabinoid Res. 2017;2(1):87-95. Published 2017 May 1. doi:10.1089\/can.2016.0032\">17<\/a><\/sup> att instabilitet i den kliniska till\u00e4mpningen av THCa-A, trots ett v\u00e4xande intresse f\u00f6r dess terapeutiska anv\u00e4ndning. Den till\u00e4gger att THCa-A saknar cannabimimetiska effekter, enligt hypotesen att den har liten bindningspotential med CB1.\r\n<\/li><\/ul>\n\n\n\n<ul><li>I motsats till ovanst\u00e5ende studie unders\u00f6ktes i en nyligen genomf\u00f6rd studie fr\u00e5n 2019 ((Arben Cuadari, Federica Pollastro, Juan D. Unciti-Broceta, Diego Caprioglio, Alberto Minassi, Annalisa Lopatriello, Eduardo Mu\u00f1oz, Orazio Taglialatela-Scafati, Giovanni Appendino,<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S221138351930379X\" target=\"_blank\" rel=\"noopener\">The dimerization of \u03949-tetrahydrocannabinolic acid A (THCA-A),<\/a>Acta Pharmaceutica Sinica B,Volume 9, Issue 5,2019,Pages 1078-1083,ISSN 2211-3835) m\u00f6jligheten till dimerisering av THCa-A f\u00f6r att l\u00f6sa problemet med decarboxylativ instabilitet. Detta skulle kunna kringg\u00e5 problemen med den kliniska till\u00e4mpligheten och st\u00f6dja utvecklingen av farmakologiska till\u00e4mpningar. <\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Slutsats\"><\/span>Slutsats<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul><li>Cannabisforskningen, dess extrakt och cannabinoider har breddat r\u00e4ckvidden f\u00f6r farmakologi och kliniska till\u00e4mpningar. Den har fr\u00e4mjat selektiv avel av specifika kemotyper och uppfinningar av syntetiska versioner som har lett till f\u00f6rb\u00e4ttringar av det terapeutiska indexet f\u00f6r cannabis. <\/li><\/ul>\n\n\n\n<ul><li>Forskningen om THCa och dess terapeutiska potential befinner sig i ett tidigt skede och skulle kunna ge positiva resultat.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Kallor\"><\/span>K\u00e4llor<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><\/p>\n<ol class=\"footnotes\"><li id=\"footnote_0_112257\" class=\"footnote\">Pertwee RG. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1760722\/\" target=\"_blank\" rel=\"noopener\">Cannabinoid pharmacology: the first 66 years.<\/a> <em>Br J Pharmacol<\/em>. 2006;147 Suppl 1(Suppl 1): S163-S171. doi:10.1038\/sj.bjp.0706406<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_0_112257\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_1_112257\" class=\"footnote\">Russo EB. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3165946\/\" target=\"_blank\" rel=\"noopener\">Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.<\/a> <em>Br J Pharmacol<\/em>. 2011;163(7):1344-1364. doi:10.1111\/j.1476-5381.2011.01238.x<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_1_112257\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_2_112257\" class=\"footnote\">Brian F. Thomas, Mahmoud A. ElSohly, Chapter 1 &#8211; <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/cannabinol\" target=\"_blank\" rel=\"noopener\">The Botany of Cannabis sativa L.<\/a>, Editor(s): Brian F. Thomas, Mahmoud A. ElSohly, The Analytical Chemistry of Cannabis, Elsevier,2016, Pages 1-26, ISBN 9780128046463<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_2_112257\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_3_112257\" class=\"footnote\">Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, Lorenzo Corsi, &#8220;<em>Cannabis sativa<\/em> L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer&#8221;, <em>BioMed Research International<\/em>, vol. 2018, Article ID 1691428, 15 pages, 2018. <a href=\"https:\/\/doi.org\/10.1155\/2018\/1691428\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1155\/2018\/1691428<\/a><span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_3_112257\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_4_112257\" class=\"footnote\">War AR, Paulraj MG, Ahmad T, et al. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3493419\/\" target=\"_blank\" rel=\"noopener\">Mechanisms of plant defense against insect herbivores.<\/a> <em>Plant Signal Behav<\/em>. 2012;7(10):1306-1320. doi:10.4161\/psb.21663<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_4_112257\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_5_112257\" class=\"footnote\">Happyana, Nizar &amp; Agnolet, Sara &amp; Muntendam, Remco &amp; Dam, Annie &amp; Schneider, Bernd &amp; Kayser, Oliver. 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Cannabis and Cannabinoid Research<\/a>. 1. 10.1089\/can.2016.0008<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_16_112257\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><li id=\"footnote_16_112257\" class=\"footnote\">McPartland JM, MacDonald C, Young M, Grant PS, Furkert DP, Glass M. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5510775\/\" target=\"_blank\" rel=\"noopener\">Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two<\/a>. <em>Cannabis Cannabinoid Res<\/em>. 2017;2(1):87-95. Published 2017 May 1. doi:10.1089\/can.2016.0032<span class=\"footnote-back-link-wrapper\"> [<a href=\"#identifier_17_112257\" class=\"footnote-link footnote-back-link\">&#8617;<\/a>]<\/span><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>THC och THCa h\u00e4rstammar fr\u00e5n samma grundsubstans CBG, men har olika egenskaper. THC eller Tetrahydrocannabinol \u00e4r en av de naturligt f\u00f6rekommande cannabinoiderna som renas fr\u00e5n cannabisplantor. Tetrahydrocannabinolsyra (THCa) \u00e4r THC:s sura prekursor. <\/p>\n","protected":false},"author":30,"featured_media":101218,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","footnotes":""},"categories":[525],"tags":[],"acf":[],"modified_by":"Hemppedia","_links":{"self":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts\/112257"}],"collection":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/users\/30"}],"replies":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/comments?post=112257"}],"version-history":[{"count":3,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts\/112257\/revisions"}],"predecessor-version":[{"id":112260,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/posts\/112257\/revisions\/112260"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/media\/101218"}],"wp:attachment":[{"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/media?parent=112257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/categories?post=112257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/old.hemppedia.org\/sv\/wp-json\/wp\/v2\/tags?post=112257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}